REORGANIZATION OF PERIPHERAL ACTIN-FILAMENTS AS A PRELUDE TO EXOCYTOSIS
REORGANIZATION OF PERIPHERAL ACTIN-FILAMENTS AS A PRELUDE TO EXOCYTOSIS
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DOI：
10.1007/bf01121449
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发表时间：
1987-04-01
影响因子：
4
通讯作者：
CHEEK, TR
中科院分区：
文献类型：
--
作者：
BURGOYNE, RD;CHEEK, TR
证据是，从肾上腺嗜铬细胞的研究，皮质肌动蛋白网络的重组是必要的，让颗粒到达受刺激的细胞中的胞吐位点。这种重组可能涉及肌动蛋白丝交联，组装和与分泌颗粒和质膜的相互作用的变化。讨论了细胞骨架元件（包括膜结合蛋白caldesmon、p70和p36）可能在胞吐之前参与颗粒-质膜相互作用的可能性。
Evidence is presented, from studies on the adrenal chromaffin cell, that reorganisation of the cortical actin network is necessary to allow granules to reach exocytotic sites in stimulated cells. This reorganisation may involve changes in actin filament cross-linking, assembly and interactions with secretory granule and plasma membranes. The possibility is discussed that cytoskeletal elements including the membrane-binding proteins caldesmon, p70 and p36 may be involved in granule-plasmalemmal interactions immediately prior to exocytosis.