PEPTIDE SPECIFICITY IN THE RECOGNITION OF MHC CLASS-I BY NATURAL-KILLER-CELL CLONES
PEPTIDE SPECIFICITY IN THE RECOGNITION OF MHC CLASS-I BY NATURAL-KILLER-CELL CLONES
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DOI：
10.1126/science.7863326
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发表时间：
1995-02-17
期刊：
影响因子：
56.9
通讯作者：
LONG, EO
中科院分区：
文献类型：
--
作者：
MALNATI, MS;PERUZZI, M;LONG, EO
自然杀伤（NK）细胞对靶细胞上主要组织相容性复合体（MHC）I类分子的识别抑制NK介导的裂解。在这里，肽结合位点单个氨基酸突变的HLA-B*2705分子对NK克隆的抑制作用在HLA-B*2705特异性NK克隆之间存在差异。此外，这样的NK克隆的一个子集被抑制的几个自我肽加载到HLA-B*2705分子在肽转运蛋白缺陷的细胞中表达，显示识别是肽特异性的。这些数据表明，与MHC I类复合的特异性自身肽提供了对NK介导的裂解的保护。
Recognition by natural killer (NK) cells of major histocompatibility complex (MHC) class I molecules on target cells inhibits NK-mediated lysis. Here, inhibition of NK clones by HLA-B*2705 molecules mutated at single amino acids in the peptide binding site varied among HLA-B*2705-specific NK clones. In addition, a subset of such NK clones was inhibited by only one of several self peptides loaded onto HLA-B*2705 molecules expressed in peptide transporter-deficient cells, showing that recognition was peptide-specific. These data demonstrate that specific self peptides, complexed with MHC class I, provide protection from NK-mediated lysis.