Real-time tracking of source movement by Cherenkov emission imaging for high-dose-rate brachytherapy
Real-time tracking of source movement by Cherenkov emission imaging for high-dose-rate brachytherapy
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DOI：
10.1088/1748-0221/17/07/t07001
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发表时间：
2022-07-01
影响因子：
1.3
通讯作者：
Yamamoto，S.
中科院分区：
文献类型：
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作者：
Yogo，K.;Tatsuno，Y.;Yamamoto，S.
源移动的质量保证（QA）对于确保高剂量率（HDR）近距离放射治疗的安全输送至关重要。本文提出了一种基于切伦科夫发射成像的高剂量率近距离放射治疗中源运动实时跟踪的简单有效方法。利用高灵敏度摄像机拍摄了192 Ir源γ射线照射水体后产生的切伦科夫光。从光图像确定源位置和停留间隔，并与预设值进行比较。从源位置的时间过程测量源停留时间和通过速度。将亮度曲线与治疗计划系统提供的剂量分布进行比较。源的运动在真实的时间被可视化为切伦科夫光发射的电影。从切伦科夫发射图像测量的源位置间隔同意以及在0.3 mm内的预设值。源停留时间在0.2 s内的预设值相媲美，和过境速度是类似的那些以前的报告。亮度分布与剂量分布在约40%以内一致，除了靠近源中心。所提出的切伦科夫方法具有良好的潜力，在近距离放射治疗的真实的时间跟踪源的运动，因为它可以使源的位置，停留时间和剂量分布的同时测量。
Quality assurance (QA) of the source movement is essential for ensuring the safe delivery of high-dose-rate (HDR) brachytherapy. Here, we proposed a simple and effective method for real-time tracking of the source movement in high-dose-rate brachytherapy based on Cherenkov emission imaging. The Cherenkov light emitted from water irradiated by 192 Ir-source γ-rays was captured using a high-sensitivity video camera. The source positions and dwell intervals were determined from the light images and compared with the preset values. The source dwell times and transit speeds were measured from the time course of the source positions. The brightness profiles were compared with the dose distributions provided by the treatment planning system. The source movements were visualized in real time as a movie of Cherenkov light emissions. The source positional intervals measured from the Cherenkov emission images agreed well to the preset values within 0.3 mm. The source dwell times were comparable to the preset values within 0.2 s, and the transit speeds were similar to those of previous reports. The brightness distributions agreed with the dose distributions within approximately 40%, except near the source center. The proposed Cherenkov method has good potential for tracking the source movement in real time in brachytherapy, as it could enable simultaneous measurements of the source positions, dwell times, and dose distributions.