Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
Economy of Operon Formation: Cotranscription Minimizes Shortfall in Protein Complexes
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DOI：
10.1128/mbio.00177-10
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发表时间：
2010-09
期刊：
影响因子：
6.4
通讯作者：
K. Sneppen;S. Pedersen;Sandeep Krishna;I. Dodd;S. Semsey
中科院分区：
文献类型：
--
作者：
K. Sneppen;S. Pedersen;Sandeep Krishna;I. Dodd;S. Semsey
原核生物和古细菌的基因通常以共转录组或操纵子的形式组织。相反，真核生物的基因通常是独立转录的。在这里，我们表明，对细胞来说，共转录编码蛋白质复合物的基因有很大的经济收益，因为它同步了不同成分水平的波动或噪音。这种相关性大大减少了复合物生产的不足。这种益处在细菌细胞等小细胞中相对较大，因为细菌细胞中每个细胞的mrna和蛋白质很少，而在真核细胞等大细胞中则有所减少。
ABSTRACT Genes of prokaryotes and Archaea are often organized in cotranscribed groups, or operons. In contrast, eukaryotic genes are generally transcribed independently. Here we show that there is a substantial economic gain for the cell to cotranscribe genes encoding protein complexes because it synchronizes the fluctuations, or noise, in the levels of the different components. This correlation substantially reduces the shortfall in production of the complex. This benefit is relatively large in small cells such as bacterial cells, in which there are few mRNAs and proteins per cell, and is diminished in larger cells such as eukaryotic cells.