Combined transcranial direct current stimulation with virtual reality exposure for posttraumatic stress disorder: Feasibility and pilot results.
Combined transcranial direct current stimulation with virtual reality exposure for posttraumatic stress disorder: Feasibility and pilot results.
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DOI：
10.1016/j.brs.2018.09.011
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发表时间：
2019-01
影响因子：
7.7
通讯作者：
Philip NS
中科院分区：
文献类型：
--
作者：
van 't Wout-Frank M;Shea MT;Larson VC;Greenberg BD;Philip NS
Facilitating neural activity using non-invasive brain stimulation may improve extinction-based treatments for posttraumatic stress disorder (PTSD). Here, we examined the feasibility of simultaneous transcranial direct current stimulation (tDCS) application during virtual reality (VR) to reduce psychophysiological arousal and symptoms in Veterans with PTSD. Twelve Veterans with PTSD received six combat-related VR exposure sessions during sham-controlled tDCS targeting ventromedial prefrontal cortex. Primary outcome measures were changes in skin conductance-based arousal and self-reported PTSD symptom severity. tDCS + VR components were combined without technical difficulty. We observed a significant interaction between reduction in arousal across sessions and tDCS group (p = .03), indicating that the decrease in physiological arousal was greater in the tDCS + VR versus sham group. We additionally observed a clinically meaningful reduction in PTSD symptom severity. This study demonstrates feasibility of applying tDCS during VR. Preliminary data suggest a reduction in psychophysiological arousal and PTSD symptomatology, supporting future studies.
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DOI：
10.1176/appi.ajp.2017.16090996
发表时间：
2017-07-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Philip NS;Nelson BG;Frohlich F;Lim KO;Widge AS;Carpenter LL
通讯作者：
Carpenter LL
影响因子：
2.7
作者：
VanElzakker MB;Dahlgren MK;Davis FC;Dubois S;Shin LM
通讯作者：
Shin LM
影响因子：
3.1
作者：
Van't Wout M;Longo SM;Reddy MK;Philip NS;Bowker MT;Greenberg BD
通讯作者：
Greenberg BD
影响因子：
7.7
作者：
van 't Wout M;Mariano TY;Garnaat SL;Reddy MK;Rasmussen SA;Greenberg BD
通讯作者：
Greenberg BD
DOI：
10.1176/appi.ajp.2014.13121625
发表时间：
2014-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Rothbaum BO;Price M;Jovanovic T;Norrholm SD;Gerardi M;Dunlop B;Davis M;Bradley B;Duncan EJ;Rizzo A;Ressler KJ
通讯作者：
Ressler KJ