Cross-sectional associations between multisensory impairment and brain volumes in older adults: Baltimore Longitudinal Study of Aging.
Cross-sectional associations between multisensory impairment and brain volumes in older adults: Baltimore Longitudinal Study of Aging.
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老年人多感觉障碍与脑容量之间的横断面关联：巴尔的摩老龄化纵向研究。
DOI：
10.1038/s41598-024-59965-w
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发表时间：
2024
影响因子：
4.6
通讯作者：
Wanigatunga,AmalA
中科院分区：
文献类型：
--
作者：
Tian,Chenxin;Schrack,JenniferA;Agrawal,Yuri;An,Yang;Cai,Yurun;Wang,Hang;Gross,AldenL;Tian,Qu;Simonsick,EleanorM;Ferrucci,Luigi;Resnick,SusanM;Wanigatunga,AmalA
感觉障碍和脑萎缩在老年人中很常见，增加了患痴呆症的风险。然而，多种同时发生的感觉损伤（视觉、本体感觉、前庭功能、嗅觉和听觉的MSI）与脑形态测量学的关联程度仍未得到研究。数据来自巴尔的摩老龄化纵向研究的208名认知功能正常的参与者（平均年龄72±10岁；59%为女性）。多元线性回归模型用于估计MSI与区域脑成像体积之间的横断面关联。对于每一个额外的感觉损伤，都有相应的眶额回和内嗅皮质体积降低，但尾状核和壳核体积增加。与< 2损伤的参与者相比，MSI参与者的额上回、眶额回、顶叶上叶和楔前叶的平均体积更小。虽然MSI在很大程度上与较低的脑容量有关，但我们的研究结果表明，MSI可能与较高的基底神经节体积有关。需要纵向分析来评估这些关联的时效性和方向性。
Sensory impairment and brain atrophy is common among older adults, increasing the risk of dementia. Yet, the degree to which multiple co-occurring sensory impairments (MSI across vision, proprioception, vestibular function, olfactory, and hearing) are associated with brain morphometry remain unexplored. Data were from 208 cognitively unimpaired participants (mean age 72 ± 10 years; 59% women) enrolled in the Baltimore Longitudinal Study of Aging. Multiple linear regression models were used to estimate cross-sectional associations between MSI and regional brain imaging volumes. For each additional sensory impairment, there were associated lower orbitofrontal gyrus and entorhinal cortex volumes but higher caudate and putamen volumes. Participants with MSI had lower mean volumes in the superior frontal gyrus, orbitofrontal gyrus, superior parietal lobe, and precuneus compared to participants with < 2 impairments. While MSI was largely associated with lower brain volumes, our results suggest the possibility that MSI was associated with higher basal ganglia volumes. Longitudinal analyses are needed to evaluate the temporality and directionality of these associations.