LIGAND-INDEPENDENT REPRESSION BY THE THYROID-HORMONE RECEPTOR-MEDIATED BY A NUCLEAR RECEPTOR CO-REPRESSOR
LIGAND-INDEPENDENT REPRESSION BY THE THYROID-HORMONE RECEPTOR-MEDIATED BY A NUCLEAR RECEPTOR CO-REPRESSOR
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DOI：
10.1038/377397a0
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发表时间：
1995-10-05
期刊：
影响因子：
64.8
通讯作者：
ROSENFELD, MG
中科院分区：
文献类型：
--
作者：
HORLEIN, AJ;NAAR, AM;ROSENFELD, MG
甲状腺激素和视黄酸受体通过充当基因表达的激活剂和阻抑剂来发挥其调节功能。相对分子质量为 270K 的核受体辅阻遏物 (N-CoR) 已被鉴定，它介导这些受体对基因转录的配体独立抑制，表明甲状腺激素和视黄酸受体抑制的分子机制类似于酵母和果蝇的辅阻遏物依赖性转录抑制机制。
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.