THE EFFECTS OF MANNITOL ON BLOOD-VISCOSITY
THE EFFECTS OF MANNITOL ON BLOOD-VISCOSITY
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DOI：
10.3171/jns.1981.55.4.0550
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发表时间：
1981-01-01
影响因子：
4.1
通讯作者：
CERRI, C
中科院分区：
文献类型：
--
作者：
BURKE, AM;QUEST, DO;CERRI, C
为了确定甘露醇对血液粘度的影响，对颅内动脉瘤开颅手术患者的静脉血进行了系列测量。在甘露醇给药前即刻、给药后30 min、2 h和4 h采集血样。对每份样本进行全血细胞计数、血清渗透压摩尔浓度和红细胞微筛研究。全血粘度在给药后30 min和2 h降低，但在4 h时没有降低。这种降低仅出现在高剪切速率下，其中红细胞变形性在确定粘度中是关键的。这种效应与红细胞压积无关。从混悬液中去除甘露醇后，红细胞变形性恢复至给药前值，表明红细胞变形性增加需要甘露醇的存在和该药物诱导的相对高渗性。红细胞刚性降低和随后全血粘度降低应增强微循环中的组织灌注。
To determine the effect of mannitol on blood viscosity, serial measurement were carried out on venous blood in patients undergoing craniotomies for intracranial aneurysms. Blood samples were drawn immediately prior to, and 30 min, 2 and 4 h after administration of mannitol. Complete blood counts, serum osmolarities and erythrocyte microsieving studies were performed on each sample. Whole-blood viscosity decreased at 30 min and 2 h, but not at 4 h after mannitol administration. This decrease appeared at high shear rates only, where erythrocyte deformability is critical in determining viscosity. This effect was independent of the hematocrit. Removal of mannitol from the suspension returned red cell deformability to preadministration values, indicating that the increased erythrocyte deformability required the presence of mannitol and the relative hyperosmolarity induced by this agent. The reduced erythrocyte rigidity and subsequent decreased whole-blood viscosity should enhance tissue perfusion in the microcirculation.