Two New Dammarane Triterpenes from the Leaves of Ceriops tagal
Two New Dammarane Triterpenes from the Leaves of Ceriops tagal
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发表时间：
2016
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通讯作者：
Xin Wu;Hong-bo Liao;Xiaohui Zhu;Hongyu Lu;Xiaobin Zeng;L. Cui;Xiaohua Lv;Yanqun Li;Chaohua Zhan
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作者：
Xin Wu;Hong-bo Liao;Xiaohui Zhu;Hongyu Lu;Xiaobin Zeng;L. Cui;Xiaohua Lv;Yanqun Li;Chaohua Zhan
从沙棘叶中分离得到两个新的达玛拉烷三萜化合物，分别为Cereotagalol C(1)和Cereotagalol D(2)。通过1D-、2D-核磁共振和HR-ESI-MS等波谱和质谱学分析确定了它们的结构。对A549、Hep G2、Hct-116和CNE2四种细胞株的细胞毒活性测定表明，化合物1和2对Hct-116和CNE-2细胞具有中等的细胞毒作用，IC50值分别为29.7和37.2μM。
Two new dammarane triterpenes, cereotagalol C (1) and cereotagalol D (2), were isolated from the leaves of Ceriops tagal. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR-ESI-MS. Their cytotoxic activities against A549, HepG2, HCT-116 and CNE2 cell lines were also evaluated, which revealed that compounds 1 and 2 had selected moderate cytotoxicity against HCT-116 and CNE-2 with IC50 values of 29.7 and 37.2 μM, respectively.