Concise review: role of DEK in stem/progenitor cell biology.
Concise review: role of DEK in stem/progenitor cell biology.
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DOI：
10.1002/stem.1443
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发表时间：
2013-08
期刊：
影响因子：
5.2
通讯作者：
Markovitz, David M.
中科院分区：
文献类型：
--
作者：
Broxmeyer, Hal E.;Mor-Vaknin, Nirit;Kappes, Ferdinand;Legendre, Maureen;Saha, Anjan K.;Ou, Xuan;O'Leary, Heather;Capitano, Maegan;Cooper, Scott;Markovitz, David M.
关键词：
了解调节造血的因素开辟了修改这些因素及其作用的可能性，以获得临床效益。DEK是一种非组蛋白核磷蛋白，最初被认为是一种假定的原癌基因，最近被认为与造血调控有关。DEK在体外对人和小鼠造血祖细胞的增殖具有骨髓抑制活性，并对长期骨髓再生小鼠干细胞的植入具有增强活性，已与转录因子C/EBPα协同调节骨髓细胞的分化，并明显靶向长期再生造血干细胞用于白血病转化。这篇综述涵盖了DEK的独特性，已知它现在如何作为一种核蛋白发挥作用，也作为一种分泌分子，可以在旁分泌的方式，以及它如何可能被调节部分由二肽基肽酶4，一种已知的截断和修改的一些蛋白质参与造血细胞的活动。提供的例子可能未来的调查领域需要更好地了解如何DEK可能被调节和造血功能的调节，信息可能翻译到其他正常和患病的不成熟细胞系统。
Understanding the factors that regulate hematopoiesis opens up the possibility of modifying these factors and their actions for clinical benefit. DEK, a non-histone nuclear phosphoprotein initially identified as a putative proto-oncogene, has recently been linked to regulation of hematopoiesis. DEK has myelosuppressive activity in vitro on proliferation of human and mouse hematopoietic progenitor cells and enhancing activity on engraftment of long term marrow repopulating mouse stem cells, has been linked in coordinate regulation with the transcription factor C/EBPα, for differentiation of myeloid cells, and apparently targets a long term repopulating hematopoietic stem cell for leukemic transformation. This review covers the uniqueness of DEK, what is known about how it now functions as a nuclear protein and also as a secreted molecule that can act in paracrine fashion, and how it may be regulated in part by Dipeptidylpeptidase 4, an enzyme known to truncate and modify a number of proteins involved in activities on hematopoietic cells. Examples are provided of possible future areas of investigation needed to better understand how DEK may be regulated and function as a regulator of hematopoiesis, information possibly translatable to other normal and diseased immature cell systems.
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影响因子：
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作者：
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发表时间：
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期刊：
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发表时间：
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期刊：
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影响因子：
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