EPITHELIAL REPAIR IN RECOVERY FROM VITAMIN A DEFICIENCY : AN EXPERIMENTAL STUDY.
EPITHELIAL REPAIR IN RECOVERY FROM VITAMIN A DEFICIENCY : AN EXPERIMENTAL STUDY.
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DOI：
10.1084/jem.57.3.511
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发表时间：
1933-02-28
期刊：
影响因子：
--
通讯作者：
Howe PR
中科院分区：
文献类型：
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作者：
Wolbach SB;Howe PR
1. 维生素 A 缺乏时，替换的复层角化上皮在所有位置的形态都相同。 2.替换上皮最下层的所有细胞均与表皮生发层一样具有增殖能力。 3.在恢复过程中，尽管形态学完全掩蔽，但每个区域的上皮细胞恢复到其正常类型。 4. 修复的重要组织学特征包括去除不可逆地分化为角化的细胞层以及将生发层直接分化为正常类型。这些都是同时发生的。 5.在去除生发层以上细胞时观察到的组织学序列表明，涉及如空泡变性所示的自溶和如白细胞浸润所示的异质溶解。 6. A缺陷化生和恢复的循环为核染色质和细胞质活性类型的相关性提供了一种实验方法。
1. In vitamin A deficiency, the replacement stratified keratinizing epithelium is morphologically identical in all locations. 2. All cells of the lowermost layer of the replacement epithelium have proliferative power as in the stratum germinativum of epidermis. 3. In recovery, in spite of the complete morphological masking, the epithelium in each region returns to its normal type. 4. The important histological features of repair involve removal of the layers of cells irreversibly differentiated towards keratinization and direct differentiation of the stratum germinativum into the normal type. These take place simultaneously. 5. The histological sequences observed in the removal of cells above the stratum germinativum indicate that autolysis as shown by vacuolar degeneration and heterolysis as shown by leucocytic infiltration are involved. 6. The cycle of A deficiency metaplasia and recovery affords an experimental method available for the correlation of nuclear chromatin and types of cytoplasmic activities.