Cytotoxic flavonoids from the flowers of Achillea millefolium
Cytotoxic flavonoids from the flowers of Achillea millefolium
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蓍草花中的细胞毒性黄酮类化合物
DOI：
10.1007/s10600-013-0438-y
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发表时间：
2013-01-01
影响因子：
0.8
通讯作者：
Kiyota, Hiromasa
中科院分区：
文献类型：
--
作者：
Huo, Chang-Hong;Li, Yong;Kiyota, Hiromasa
从千叶阿喀琉叶（Achillea millefolium）花中分离得到一个新的天然产物8,8′-bi-3- o -甲基槲皮素(9)和8个已知的黄酮类化合物。它们的结构是根据光谱证据确定的。这些化合物的所有光谱数据都是在对其二维核磁共振光谱数据进行解释后重新分配的。化合物2、5和7对人乳腺癌细胞系MCF7WT具有抗增殖活性。另外，2和5对人前列腺癌细胞PC-3具有抗增殖活性，而其他化合物对两种人肿瘤细胞系均无抑制作用。
A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.