Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis
Genetic causal association between rheumatoid arthritis and periodontitis: a bidirectional two-sample Mendelian randomization analysis
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DOI：
10.1007/s00784-024-05512-w
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发表时间：
2024-01-20
影响因子：
3.4
通讯作者：
Chen，Xiaoyan
中科院分区：
文献类型：
--
作者：
Cheng，Zijian;Gao，Lu;Chen，Xiaoyan
背景类风湿性关节炎（RA）和牙周炎（PD）之间的联系已被证实。然而，它们的因果关系仍不清楚，并且不同血清型 RA 对 PD 发展的影响尚未得到研究。本研究旨在利用孟德尔随机化 (MR) 阐明 PD 与不同血清型 RA 之间的因果关系。方法使用现有的大规模全基因组关联研究统计数据进行双向双样本 MR 分析。根据工具变量的异质性，使用逆方差加权 (IVW) 或乘性随机效应 IVW 来确定因果关系。还进行了额外的敏感性分析。结果前瞻性 MR 分析发现，血清阳性 RA（比值比 (OR)，1.26；95% 置信区间 (CI)，1.07–1.44；p= 0.0018）与血清阴性 RA（OR，1.01；95% CI，0.95–1.06；p= 0.9098）无关。 PD 风险增加。反向 MR 分析未显示 PD 对 RA 的任何显着因果影响，与血清型无关。敏感性测试 (p> 0.05) 证实了这些研究结果的稳健性和准确性。 结论 这项研究揭示了血清阳性 RA 对 PD 存在遗传因果效应，表明这种亚型 RA 患者可能需要特殊的临床关注以预防 PD 的发展。
BackgroundA link between rheumatoid arthritis (RA) and periodontitis (PD) has been established. However, their causal relationship remains unclear and the effect of different serotypes of RA on the PD development has not been investigated. This study aims to elucidate the causal association between PD and different serotypes of RA using Mendelian randomization (MR).MethodsA bidirectional two-sample MR analysis was performed using available large-scale genome-wide association studies statistics. The inverse-variance weighted (IVW) or multiplicative random-effects IVW was used to determine causality, depending on the heterogeneity of instrumental variables. Additional sensitivity analyses were also performed.ResultsThe forward MR analysis identified that seropositive RA (odds ratio (OR), 1.26; 95% confidence interval (CI), 1.07–1.44;p= 0.0018), but not seronegative RA (OR, 1.01; 95% CI, 0.95–1.06;p= 0.9098), was associated with an increased risk of PD. The reverse MR analysis did not show any significant causal effect of PD on RA, independent of the serotypes. The sensitivity tests (p> 0.05) confirmed the robustness and accuracy of these findings.ConclusionThis study revealed that there was a genetic causal effect of seropositive RA on PD, suggesting that this subtype of RA patients may require specific clinical attention to prevent the development of PD.