IUPred:: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
IUPred:: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content
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DOI：
10.1093/bioinformatics/bti541
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发表时间：
2005-08-15
期刊：
影响因子：
5.8
通讯作者：
Simon, I
中科院分区：
文献类型：
--
作者：
Dosztányi, Z;Csizmok, V;Simon, I
非结构化/无序蛋白质和结构域（IUP）在天然条件下缺乏明确的三维结构。IUPred服务器提出了一种新的算法，通过估计它们的总成对残基间相互作用能，从氨基酸序列预测这样的区域，基于UP序列不折叠的假设，由于它们不能形成足够的稳定残基间相互作用。可选的预测是内置的参数集优化预测短或长的无序区域和结构域。
Intrinsically unstructured/disordered proteins and domains (IUPs) lack a well-defined three-dimensional structure under native conditions. The IUPred server presents a novel algorithm for predicting such regions from amino acid sequences by estimating their total pairwise interresidue interaction energy, based on the assumption that UP sequences do not fold due to their inability to form sufficient stabilizing interresidue interactions. Optional to the prediction are built-in parameter sets optimized for predicting short or long disordered regions and structured domains.