Renal sympathetic denervation suppresses atrial fibrillation induced by acute atrial ischemia/infarction through inhibition of cardiac sympathetic activity
Renal sympathetic denervation suppresses atrial fibrillation induced by acute atrial ischemia/infarction through inhibition of cardiac sympathetic activity
复制标题
去肾交感神经通过抑制心脏交感神经活性来抑制急性心房缺血/梗死引起的心房颤动
DOI：
10.1016/j.ijcard.2015.10.120
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发表时间：
2015
影响因子：
3.5
通讯作者：
Baopeng Tang
中科院分区：
文献类型：
--
作者：
Qina Zhou;Zhou X;ZuKe-la TuEr-Hong;Hongli Wang;Tingting Yin;Yaodong Li;Ling Zhang;Yanmei Lu;Yanmei Lu;Jianghua Zhang;Yining Yang;Baopeng Tang
目的：探讨肾交感神经去支配（RSD）对急性心房缺血/梗死心房颤动（AF）诱发性及交感神经活动的影响。方法：结扎供应心房的冠状动脉诱导12只beagle犬急性缺血/梗死。假RSD组的6只狗没有进行RSD， 6只没有冠状动脉结扎的狗作为对照。测定心房颤动诱导率、交感放电、儿茶酚胺浓度和酪氨酸羟化酶阳性神经密度。结果：急性心房缺血/梗死组AF诱导率显著升高，RSD较对照组降低（P < 0.05）。心房缺血组交感神经放电的均方根峰值、峰面积和次数均明显高于对照组（P < 0.05）。与对照组和假RSD组相比，RSD组交感神经放电次数明显减少（P < 0.05）。心房缺血/梗死后，去甲肾上腺素和肾上腺素在心房、心室和肾脏的浓度升高，但RSD降低（P < 0.05）。结论：交感神经亢进与急性心房缺血/梗死后起搏性房颤有关。RSD有可能降低急性心房缺血/梗死后新发房颤的发生率。RSD对心脏交感神经活动的抑制可能是其显著的潜在机制之一。AF诱导率降低。
Objective: This study aims to explore the effects of renal sympathetic denervation (RSD) on atrial fibrillation (AF) inducibility and sympathetic activity induced by acute atrial ischemia/infarction. Methods: Acute ischemia/infarction was induced in 12 beagle dogs by ligating coronary arteries that supply the atria. Six dogs in the sham-RSD group did not undergo RSD, and six dogs without coronary artery ligation served as controls. AF induction rate, sympathetic discharge, catecholamine concentration and densities of tyrosine hydroxylase-positive nerves were measured. Results: Acute atrial ischemia/infarction resulted in a significant increase of AF induction rate, which was decreased by RSD compared to controls (P < 0.05). The root-mean-square peak value, peak area and number of sympathetic discharges were significantly augmented by atrial ischemia relative to the baseline and control (P < 0.05). The number of sympathetic discharges was significantly reduced in the RSD group, compared to the control and sham-RSD groups (P < 0.05). Norepinephrine and epinephrine concentrations in the atria, ventricle and kidney were elevated by atrial ischemia/infarction, but were reduced by RSD (P < 0.05). Conclusions: Sympathetic hyperactivity was associated with pacing-induced AF after acute atrial ischemia/infarction. RSD has the potential to reduce the incidence of new-onset AF after acute atrial ischemia/infarction. The inhibition of cardiac sympathetic activity by RSD may be one of the major underlying mechanisms for the marked.reduction of AF inducibility.