The murine Xe169 gene escapes X-inactivation like its human homologue.
The murine Xe169 gene escapes X-inactivation like its human homologue.
复制标题
鼠类 Xe169 基因像其人类同源基因一样逃脱了 X 失活。
DOI：
10.1038/ng0894-491
复制
发表时间：
1994
期刊：
影响因子：
30.8
通讯作者：
Shapiro,LJ
中科院分区：
文献类型：
--
作者：
Wu,J;Salido,EC;Yen,PH;Mohandas,TK;Heng,HH;Tsui,LC;Park,J;Chapman,VM;Shapiro,LJ
在人类中逃脱X染色体失活的许多基因中，有三个已经在小鼠中进行了评估，出乎意料的是，所有三个都受到X失活的影响。本文报道了一个新的小鼠基因Xe 169的克隆和表达研究，该基因与人类同源基因一样能逃避X染色体失活，荧光原位杂交结果表明Xe 169位于小鼠X染色体上的F2/F3带，Southern分析表明该基因位于假常染色体区域之外。Xe 169是第一个在小鼠体内克隆的非假常染色体基因，它在活性和失活的X染色体上都有表达。
Among a number of genes that escape X–chromosome inactivation in humans, three have been evaluated in mice and unexpectedly all three are subject to X–inactivation. We report here the cloning and expression studies of a novel mouse gene,Xe169, and show that it escapes X–inactivation like its human homologue.Xe169was assigned to band F2/F3 on the mouse X chromosome by fluorescentin situhybridization and Southern analysis indicates that the gene is located outside the pseudoautosomal region. Homologous, but divergent, sequences exist on the Y chromosome.In vitroandin vivostudies show thatXe169is expressed from both the active and the inactive X chromosomes.Xe169is the first cloned non–pseudoautosomal gene that escapes X–inactivaton in mice.