Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults
Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adults
复制标题
DOI：
10.1162/jocn.2007.19.10.1624
复制
发表时间：
2007-10-01
影响因子：
3.2
通讯作者：
Braff, David L.
中科院分区：
文献类型：
--
作者：
Light, Gregory A.;Swerdlow, Neal R.;Braff, David L.
了解复杂的高阶认知操作和心理社会功能背后的基本神经过程是认知神经科学的基本目标。事件相关电位使研究人员能够探索信息处理的最早阶段。失配负性（MMN）和 P3a 是反映自动感觉、辨别力的听觉事件相关电位成分。本研究的目的是确定 MMN 和 P3a 是否与临床正常健康受试者的高级认知操作和心理社会功能相关。使用标准化的临床、认知和心理社会功能工具对 20 名成年人进行了评估。所有个体的认知测试和功能评级均在正常范围内。参与者还接受了持续时间偏差 MMN/P3a 范式的测试（50 毫秒标准音调，p = .90；100 毫秒异常音调，p = .10；刺激开始异步 [SOA] = 505 毫秒）。在额中央电极区域，观察到心理社会功能与 MMN (r = -.62，p < .01) 和 P3a (r = .63，P < .01) 振幅之间存在显着相关性。 P3a 幅度还与口头信息的即时和延迟回忆高度相关，并且具有广泛分布在额中央记录区域的强大相关性（例如，r = .72，p < .001）。 P3a 反应的潜伏期与工作记忆性能 (r = -.53, p < .05) 和功能评分 (r = -.48, p < .05) 显着相关。相对自动的听觉感觉信息处理的神经生理学测量与正常受试者的高阶认知能力和心理社会功能相关。基本水平的信息处理效率可能是成功编码、检索和区分任务相关信息的基础，这反过来又促进了适应性认知和社会功能所需的迭代和响应处理。
Understanding the basic neural processes that underlie complex higher order cognitive operations and psychosocial functioning is a fundamental goal of cognitive neuroscience. Event-related potentials allow investigators to probe the earliest Stages of information processing. Mismatch negativity (MMN) and P3a are auditory event-related potential components that reflect automatic sensory, discrimination. The aim of the present study was to determine if MMN and P3a are associated with higher order cognitive operations and psychosocial functioning in clinically normal healthy Subjects. Twenty adults were assessed using standardized clinical, cognitive, and psychosocial functional instruments. All individuals were within the normal range on cognitive tests and functional ratings. Participants were also tested on a duration-deviant MMN/P3a paradigm (50-msec standard tones, p = .90; 100-msec deviant tones, p = .10; stimulus onset asynchrony [SOA] = 505 msec). Across fronto-central electrode regions, significant correlations were observed between psychosocial functioning and MMN (r = -.62, p < .01) and P3a (r = .63, P < .01) amplitudes. P3a amplitude was also highly associated with immediate and delayed recall of verbal information with robust correlations widely distributed across fronto-central recording areas (e.g., r = .72, p < .001). The latency of the P3a response was significantly associated with both working memory performance (r = -.53, p < .05) and functional ratings (r = -.48, p < .05). Neurophysiological measures of relatively automatic auditory sensory information processing are associated with higher order cognitive abilities and psychosocial functioning in normal subjects. Efficiency at elementary levels Of information processing may underlie the successful encoding, retrieval, and discrimination of task-relevant information, which, in turn, facilitates the iterative and responsive processing necessary for adaptive cognitive and social functioning.