Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence
Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence
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DOI：
10.1001/jamapsychiatry.2017.2269
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发表时间：
2017-11-01
期刊：
影响因子：
25.8
通讯作者：
Han, Shizhong
中科院分区：
文献类型：
--
作者：
Andersen, Allan M.;Pietrzak, Robert H.;Han, Shizhong
重要性重度抑郁症（MDD）和酒精依赖（AD）是具有重大公共卫生负担的遗传性疾病，并且它们经常共病。共同的遗传因素，影响共同发生的抑郁症和AD已寻求在家庭，双胞胎，并通过研究，结果到目前为止已经有希望，但不确定。对MDD多基因风险评分（PRS）与AD病例数的相关性进行分析。来自4个独立的全基因组关联研究（GWAS）数据集的欧洲血统样本的对照状态：酒精中毒遗传学合作研究（COGA）;成瘾、遗传学和环境研究（SAGE）;耶鲁-宾夕法尼亚物质依赖遗传学研究;以及退伍军人国家健康和复原力研究（NHRVS）。来自精神病基因组学联盟的MDD荟萃分析（9240例MDD患者和9519例对照）的结果被应用于计算PRS，阈值为P <0.05至P <0.05。
IMPORTANCE Major depressive disorder (MDD) and alcohol dependence (AD) are heritable disorders with significant public health burdens, and they are frequently comorbid. Common genetic factors that influence the co-occurrence of MDD and AD have been sought in family, twin, and adoption studies, and results to date have been promising but inconclusive.OBJECTIVE To examine whether AD and MDD overlap genetically, using a polygenic score approach.DESIGN, SETTINGS, AND PARTICIPANTS Association analyses were conducted between MDD polygenic risk score (PRS) and AD case-control status in European ancestry samples from 4 independent genome-wide association study (GWAS) data sets: the Collaborative Study on the Genetics of Alcoholism (COGA); the Study of Addiction, Genetics, and Environment (SAGE); the Yale-Penn genetic study of substance dependence; and the National Health and Resilience in Veterans Study (NHRVS). Results from a meta-analysis of MDD (9240 patients with MDD and 9519 controls) from the Psychiatric Genomics Consortium were applied to calculate PRS at thresholds from P < .05 to P