In vivo confocal microscopy evaluation of ocular and cutaneous alterations in patients with rosacea
In vivo confocal microscopy evaluation of ocular and cutaneous alterations in patients with rosacea
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DOI：
10.1136/bjophthalmol-2015-308110
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发表时间：
2017-03-01
影响因子：
4.1
通讯作者：
Baudouin, Christophe
中科院分区：
文献类型：
--
作者：
Liang, Hong;Randon, Matthieu;Baudouin, Christophe
目的酒渣鼻的生理病理机制以及眼和皮肤酒渣鼻之间的关系尚不清楚。本研究利用活体共聚焦显微镜(IVCM)对眼及皮肤酒渣鼻进行分析。方法对34例(34只眼)确诊为酒渣鼻相关汗腺功能障碍的蒸发性干眼患者进行研究。眼科检查包括干眼眼表疾病指数(OSDI)、Schirmer试验、泪液渗透压、泪液破裂时间、牛津评分、红外线眼底照相分析眉板腺(MG)和IVCM检查角膜、MG和皮肤分析(面颊、手)。此外，还调查了MG和脸颊中蠕形螨的存在情况。我们建立了MG(IVCM-MG)和面颊(IVCM-Cheek)MG改变的量化评分，以及MG和面颊蠕形螨定量评分(IVCM-MG-Dex和IVCM-Cheek-Dex)。结果IVCM对角膜和MG结构的分析具有相关性，也适用于皮肤分析。裸露的皮肤探查清楚地显示了表皮和真皮层。在酒渣鼻患者中，IVCM-MG改变评分与IVCM-Cheek相关(R2=0.27，P=0.0006)，IVCM-MG-Dex与IVCM-Cheek-Dex相关(R2=0.7，P<0.05)。
Aims The physiopathology of rosacea and the correlation between ocular and cutaneous rosacea remains unclear. This study analysed ocular and cutaneous rosacea with in vivo confocal microscopy (IVCM).Methods Thirty-four eyes of 34 patients with confirmed rosacea-associated meibomian gland dysfunction-related evaporative dry eye were enrolled in the study. The ophthalmological investigations included dry eye ocular surface disease index (OSDI), the Schirmer test, tear osmolarity, tear break up time, the Oxford score, infrared meibography for meibomian gland (MG) analysis and IVCM investigation for cornea, MG and skin analysis (cheek, hand). Presences of Demodex in the MG and in the cheek were also investigated. We established scores for quantifying the MG alterations in the MG (IVCM-MG) and cheek (IVCM-Cheek), and scores for Demodex quantification in the MG and cheek (IVCM-MG-Dex and IVCM-Cheek-Dex).Results IVCM was relevant for analysing the cornea and MG structures and was also suitable for cutaneous analysis. Exposed skin explorations presented the epidermal and dermal layers clearly. In patients with rosacea, the IVCM-MG alteration scores were correlated with IVCM-Cheek (R-2=0.27 and p=0.0006) and IVCM-MG-Dex was correlated with IVCM-Cheek-Dex (R-2=0.70 and p