Comparison of Recruitment Efforts Targeted at Primary Care Physicians Versus the Community at Large for Participation in Alzheimer Disease Clinical Trials
Comparison of Recruitment Efforts Targeted at Primary Care Physicians Versus the Community at Large for Participation in Alzheimer Disease Clinical Trials
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DOI：
10.1097/wad.0b013e3181aba927
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发表时间：
2010-04-01
影响因子：
2.1
通讯作者：
Jicha, Gregory A.
中科院分区：
文献类型：
--
作者：
Carr, Sarah A.;Davis, Roberta;Jicha, Gregory A.
阿尔茨海默病临床试验招募效率低和延迟是阻碍发现更有效的治疗策略以对抗这种疾病的主要障碍。尽管普遍认识到这一问题，有限的经验数据表明，具体的招聘战略的有效性，可用于指导招聘工作。本研究旨在评估招募工作的有效性，无论是针对初级保健卫生专业人员（PCP）或患者和家庭与社区基层外展活动。主要结果测量是干预后4个月的实际研究招募和参与。没有从PCP干预中招募研究对象，而69名受试者从社区基层外展活动中招募到临床研究中（0% vs. 28%，P < 0.0001，Fisher精确检验）。PCP组招募成功的障碍包括认为参与研究会对受试者造成伤害，以及担心因参与临床研究而失去患者。我们的研究结果表明，针对潜在研究对象/护理人员的外展工作不仅具有成本效益，而且能够轻松实现直接招募临床研究的预期结果。
Inefficient and delayed recruitment into clinical trials in Alzheimer disease are major obstacles impeding progress in the discovery of more effective therapeutic strategies to combat this disease. Despite widespread recognition of this problem, limited empirical data demonstrating the effectiveness of specific recruitment strategies are available to guide recruitment endeavors. This study was designed to evaluate the effectiveness of recruitment efforts targeting either the primary care health professionals (PCPs) or patients and families with a community grass-roots outreach event. The primary outcome measure was actual study recruitment and participation in the 4 months postintervention. No research subjects were recruited from the PCP intervention, whereas 69 subjects were recruited into clinical studies from the community grass-roots outreach event activity (0% vs. 28%, P < 0.0001, Fisher exact test). Barriers to recruitment success in the PCP arm included a perception of perceived harm to subjects from research participation and fear of losing patients through clinical research participation. Our results suggest that outreach efforts directed at the potential study subject/caregiver are not only cost-effective but are able to easily accomplish the desired result of direct recruitment into clinical research studies.