Successful resolution of dermatophyte mycetoma following terbinafine treatment in two cats
Successful resolution of dermatophyte mycetoma following terbinafine treatment in two cats
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DOI：
10.1111/j.1365-3164.2008.00712.x
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发表时间：
2008-12-01
影响因子：
1.4
通讯作者：
McEwan, N. A.
中科院分区：
文献类型：
--
作者：
Nuttall, T. J.;German, A. J.;McEwan, N. A.
从两只患有全身性皮肤癣菌病和皮肤癣菌菌肿的猫中分离出对伊曲康唑和特比萘芬敏感的犬小孢子菌。伊曲康唑治疗因一只猫（波斯猫）缺乏疗效而另一只猫（缅因猫）出现不可接受的副作用而被撤回。每24小时口服（PO）26-31 mg kg(-1)特比萘芬治疗12-14周后，两只猫均获得了临床和真菌学治愈。经过 7 周的治疗后，缅因猫的临床症状完全消失。经过四个星期的治疗，并每周额外用 2% 洗必泰/2% 咪康唑洗发水清洗，剪毛后，波斯猫的足菌肿减少了 98%，然后通过手术切除。波斯猫复发性全身性皮肤癣菌病采用脉冲疗法治疗，每 24 小时口服 26 mg kg(-1) 特比萘芬，每月 1 周。尽管进行了广泛的调查，但在两只猫中均未发现诱发皮肤癣菌病的潜在疾病。特比萘芬给药与波斯猫轻度至中度嗜睡有关，但没有发现其他不良反应或血液参数变化。据作者所知，这是缅因猫皮肤癣菌菌肿的第一份报告，也是猫在接受特比萘芬治疗后成功解决这种情况的报告。
Microsporum canis sensitive to itraconazole and terbinafine was isolated from two cats presented with generalized dermatophytosis and dermatophyte mycetoma. Itraconazole therapy was withdrawn through lack of efficacy in one cat (a Persian) and unacceptable adverse effects in the other (a Maine Coon). Both cats achieved clinical and mycological cure after 12-14 weeks therapy with 26-31 mg kg(-1) terbinafine every 24 h per os (PO). Clinical signs in the Maine Coon resolved completely after 7 weeks treatment. Four weeks of therapy with additional weekly washes with a 2% chlorhexidine/2% miconazole shampoo following clipping produced a 98% reduction in the Persian cat's mycetoma, which was then surgically excised. Recurrent generalized dermatophytosis in the Persian cat has been managed with pulse therapy with 26 mg kg(-1) terbinafine every 24 h PO for 1 week in every month. No underlying conditions predisposing to dermatophytosis were found in either cat despite extensive investigation. Terbinafine administration was associated with mild to moderate lethargy in the Persian cat, but no other adverse effects or changes in blood parameters were seen. To the best of the authors' knowledge this is the first report of a dermatophyte mycetoma in a Maine Coon and of successful resolution of this condition in cats following terbinafine therapy.