Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice
Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice
复制标题
鼻塞诱导短期用力口呼吸对小鼠呼吸功能的影响
DOI：
10.1016/j.resp.2014.09.024
复制
发表时间：
2015-01-01
影响因子：
2.3
通讯作者：
Zhong, Nanshan
中科院分区：
文献类型：
--
作者：
Xie, Jiaxing;Xi, Yin;Zhong, Nanshan
Inconsistent findings regarding the experimental nasal obstruction on respiratory functions in small animals have been reported. The purpose of this study was to investigate the impact of short term forced oral breathing on respiratory functions as well as the therapeutic implication of esophageal intubation in BALB/c mice. Thirty BALB/c mice were randomized equally to two groups: an experimental group and control group. Oral breathing was induced by applying petrolatum ointment in nostrils for occlusion both nasal cavities. Esophageal tube was inserted to enlarge the oropharyngeal airway in the experimental mice. Respiratory parameters were measured by barometric whole-body plethysmography (WBP) in the following condition: normal nasal breathing; nasal breathing loading in a soft bag; forced oral breathing loading in a soft bag; forced oral breathing loading in a soft bag after undergoing esophageal intubation. After applying petrolatum ointment of nostrils, all the mice switch to oral breathing with apparent discomfort (bradypnea). Nasal occlusion was associated with a decrease in the average respiratory rate (268 +/- 36 vs. 90 +/- 10 breaths/min; P
