Protein SUMOylation modification and its associations with disease.
Protein SUMOylation modification and its associations with disease.
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蛋白质SUMO化修饰及其与疾病的关系
DOI：
10.1098/rsob.170167
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发表时间：
2017-10
期刊：
影响因子：
5.8
通讯作者：
Liang S
中科院分区：
文献类型：
--
作者：
Yang Y;He Y;Wang X;Liang Z;He G;Zhang P;Zhu H;Xu N;Liang S
苏莫化作为一种翻译后修饰，在细胞生长、迁移、应激反应和肿瘤发生等多种生物学功能中发挥着重要作用。糖基化和去糖基化的失衡与多种疾病的发生和发展密切相关。本文综述和讨论了蛋白质SUMO化和泛素化之间的信号串扰，蛋白质SUMO化与多种疾病的关系，以及SUMO化位点的识别方法。随着生物信息学和质谱学的不断发展，人们已经实现了多种准确、高通量的方法来寻找小的泛素样修饰物修饰的底物和位点，这有助于破译蛋白质SUMO化介导的疾病分子机制。
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and progression of various diseases. Herein, we summarize and discuss the signal crosstalk between SUMOylation and ubiquitination of proteins, protein SUMOylation relations with several diseases, and the identification approaches for SUMOylation site. With the continuous development of bioinformatics and mass spectrometry, several accurate and high-throughput methods have been implemented to explore small ubiquitin-like modifier-modified substrates and sites, which is helpful for deciphering protein SUMOylation-mediated molecular mechanisms of disease.
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