Database and tools for analysis of topographic organization and map transformations in major projection systems of the brain
Database and tools for analysis of topographic organization and map transformations in major projection systems of the brain
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DOI：
10.1016/j.neuroscience.2005.06.036
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发表时间：
2005-01-01
期刊：
影响因子：
3.3
通讯作者：
Darin, D
中科院分区：
文献类型：
--
作者：
Bjaalie, JG;Leergaard, TB;Darin, D
要建立新的知识，需要整合从大脑收集的分散而复杂的信息。但是，整合可能会受到严格的演示格式，实验室之间的数据格式的多样性，以及缺乏对低层次数据的访问的阻碍。我们已经解决了一些基本问题，这一挑战的解剖数据的水平，通过生产一个基于坐标的数字地图集和数据库应用程序的一个主要的投影系统在大鼠大脑：小脑-桥脑-小脑系统。该应用程序，大鼠脑-小脑系统的功能解剖学（FACCS），可通过啮齿动物脑工作台（http：//www.rbwb.org/）获得。所包括的数据是描述用轴突追踪技术标记的组织元素（轴突的轴突末端场或细胞体）的精确分布的x、y、z坐标列表。所有数据均转换为通用的局部坐标系，以便于进行动物间比较。搜索能力允许基于例如示踪剂注入部位的位置、示踪剂类别、注入部位的大小和贡献作者进行查询。图形搜索工具允许用户在坐标系内移动体积光标，以检测与选定密度水平的特定组织体积具有连接的特定注射部位。其中包括选定数据的可视化和分析工具，以及下载单个数据集以供进一步分析的选项。通过该应用程序，来自不同实验的数据和元数据被映射到相同的信息结构中，并可用于以新颖的组合进行重新使用和重新分析。该应用程序为将来处理来自其他投影系统的数据以及其他数据类别做好了准备。(c)2005年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Integration of dispersed and complicated information collected from the brain is needed to build new knowledge. But integration may be hampered by rigid presentation formats, diversity of data formats among laboratories, and lack of access to lower level data. We have addressed some of the fundamental issues related to this challenge at the level of anatomical data, by producing a coordinate based digital atlas and database application for a major projection system in the rat brain: the cerebro-ponto-cerebellar system. This application, Functional Anatomy of the Cerebro-Cerebellar System in rat (FACCS), is available via the Rodent Brain WorkBench (http://www.rbwb.org/). The data included are x,y,z-coordinate lists describing exact distributions of tissue elements (axonal terminal fields of axons, or cell bodies) that are labeled with axonal tracing techniques. All data are translated to a common local coordinate system to facilitate across animal comparison. A search capability allows queries based on, e.g. location of tracer injection sites, tracer category, size of the injection sites, and contributing author. A graphic search tool allows the user to move a volume cursor inside a coordinate system to detect particular injection sites having connections to a specific tissue volume at chosen density levels. Tools for visualization and analysis of selected data are included, as well as an option to download individual data sets for further analysis. With this application, data and metadata from different experiments are mapped into the same information structure and made available for re-use and re-analysis in novel combinations. The application is prepared for future handling of data from other projection systems as well as other data categories. (c) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.