The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover.
The role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnover.
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DOI：
10.1042/bst20120100
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发表时间：
2012-08
影响因子：
3.9
通讯作者：
Gray NK
中科院分区：
文献类型：
--
作者：
Brook M;Gray NK
胞质多聚A结合蛋白（ppabps）在促进mRNA翻译中的作用已被广泛研究。然而，PABPs在mRNA转换中也有不太明确的功能，包括默认死基化的作用，这是mRNA衰变的主要限速步骤，以及通过顺式作用的控制元件调节mRNA转换和检测异常mRNA转录物的作用。在本文中，我们回顾了我们目前对PABP1在mRNA转换中的复杂作用的理解，重点介绍了哺乳动物的最新进展，并强调了一些仍有待解决的主要问题。
The function of cytoplasmic PABPs [poly(A)-binding proteins] in promoting mRNA translation has been intensively studied. However, PABPs also have less clearly defined functions in mRNA turnover including roles in default deadenylation, a major rate-limiting step in mRNA decay, as well as roles in the regulation of mRNA turnover by cis-acting control elements and in the detection of aberrant mRNA transcripts. In the present paper, we review our current understanding of the complex roles of PABP1 in mRNA turnover, focusing on recent progress in mammals and highlighting some of the major questions that remain to be addressed.