Knockdown of LINC01116 inhibits cell migration and invasion in head and neck squamous cell carcinoma through epithelial-mesenchymal transition pathway
Knockdown of LINC01116 inhibits cell migration and invasion in head and neck squamous cell carcinoma through epithelial-mesenchymal transition pathway
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LINC01116的敲低通过上皮间质转化途径抑制头颈鳞状细胞癌的细胞迁移和侵袭
DOI：
10.1002/jcb.29331
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发表时间：
2020
影响因子：
4
通讯作者：
He Dong
中科院分区：
文献类型：
--
作者：
Wu Jing;Chen Zhizhao;Zhang Li;Cao Jun;Li Xiaoyu;Gong Zhaojian;Bo Hao;Zhang Shanshan;He Dong
长链非编码rna （lncRNAs）与肿瘤的发生和进展有关。本研究的目的是确定LINC01116在头颈部鳞状细胞癌（HNSCC）中的预后意义和生物学作用。我们确定了21个异常表达的HNSCC特异性lncrna，这些lncrna在两个微阵列数据集中很常见。通过在线基因表达谱互动分析平台分析，LINC01116在HNSCC组织中高度过表达，与较短的总生存期和无复发生存期相关。LINC01116也在口腔鳞状细胞癌和鼻咽癌组织中过表达，并且LINC01116沉默通过阻断上皮-间质转化过程显著抑制了这两种细胞系的迁移和侵袭能力。此外，通过circlncRNAnet鉴定出125个共表达基因，这些基因主要位于人类常染色体上，富集于转化生长因子- β信号通路。这些发现表明LINC01116可能是HNSCC的潜在治疗靶点。
Long noncoding RNAs (lncRNAs) are linked to tumor development and progression. The aim of this study was to determine the prognostic significance and biological role of LINC01116 in head and neck squamous cell carcinoma (HNSCC). We identified 21 aberrantly expressed lncRNAs specific to HNSCC that were common in two microarray datasets. LINC01116 was highly overexpressed in HNSCC tissues and was correlated to shorter overall survival and relapse‐free survival duration, as analyzed by the online Gene Expression Profiling Interactive Analysis platform. LINC01116 was also overexpressed in oral squamous cell carcinoma and nasopharyngeal carcinoma tissues, and LINC01116 silencing significantly inhibited the migration and invasion capacities of both cell lines by blocking the epithelial‐mesenchymal transition process. In addition, 125 coexpressing genes were identified by circlncRNAnet, and were mainly located on human autosomes and enriched in transforming growth factor‐β signaling pathway. These findings indicate that LINC01116 might be a potential therapeutic target for HNSCC.