Pathological considerations to irradiation of cavernous malformations.
Pathological considerations to irradiation of cavernous malformations.
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DOI：
10.1159/000100122
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Szeifert, Gyorgy T
中科院分区：
文献类型：
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作者：
Nyary, Istvan;Major, Otto;Szeifert, Gyorgy T
立体定向放射外科治疗脑海绵状血管畸形是一种有争议的治疗方法。对辐照标本进行系统的病理学研究可能有助于解决这一争议。40-戈伊照射后1年手术切除的丘脑CVM的光镜检查显示海绵状通道中的内皮细胞破坏，并且在病变的结缔基质中具有瘢痕组织形成的显著纤维化。这些组织病理学结果与伽玛刀手术后动静脉畸形中描述的结果相似，表明辐射能量的电离效应也引起了AVM中血管和结缔组织基质的变化。
Stereotactic radiosurgery is a controversial treatment modality in the management of cerebral cavernous malformations (CVMs). Systematic pathological studies of irradiated specimens probably could help to resolve the controversy. Light microscopic investigation of a surgically resected thalamic CVM 1 year after 40-Gy irradiation revealed endothelial cell destruction in the cavernous channels, and marked fibrosis with scar tissue formation in the connective stroma of the lesion. These histopathological findings were similar to those described in arteriovenous malformations after Gamma Knife surgery, and suggest that the ionizing effect of radiation energy evokes vascular and connective tissue stroma changes in CVMs as well.