Limits of 8-Tesla magnetic resonance imaging spatial resolution of the deoxygenated cerebral microvasculature
Limits of 8-Tesla magnetic resonance imaging spatial resolution of the deoxygenated cerebral microvasculature
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DOI：
10.1002/jmri.20006
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发表时间：
2004-03-01
影响因子：
4.4
通讯作者：
Chakeres, DW
中科院分区：
文献类型：
--
作者：
Dashner, RA;Kangarlu, A;Chakeres, DW
(P)目的：量化8 T时人类大脑可见脱氧显微血管的最低磁共振成像（MRI）空间分辨率。材料和方法：本研究将8 T梯度回波（GE）图像（平面分辨率为195 x 195）与同一尸体大脑205个冷冻组切片的相应数字照片进行比较，并将25个连续冷冻组切片的汇总图像进行比较。使用类似于常用的8t人体活体成像技术，获得1 cm厚非固定全冠状脑切片的1毫米厚GE图像。结果：脑内缺氧微观血管的MR显示非常好，分辨率约为100 μ m。结论：利用基于磁化率的血氧水平依赖（BOLD）对比，可以使用全身8-T MRI系统可视化小于成像像素尺寸的缺氧微观血管。
(P)urpose: To quantify the minimum magnetic resonance imaging (MRI) spatial resolution of the visible deoxygenated microscopic vessels of the human brain at 8 T.Materials and Methods: This study compared 8 T gradient echo (GE) images of a human cadaver brain having an in plane resolution of 195 x 195 mum to corresponding digital photographs of 205 cryomicrotome sections of the same cadaver brain, along with summed images of 25 contiguous cryomicrotome sections. One-millimeter-thick GE images of a 1 cm-thick unfixed whole coronal brain section were acquired using techniques similar to those commonly utilized for 8 T human imaging in vivo.Results: There was excellent MR visualization of the deoxygenated microscopic vessels within the brain down to a resolution of approximately 100 mum.Conclusions: By taking advantage of magnetic susceptibility-based blood oxygenation level-dependent (BOLD) contrast, deoxygenated microscopic blood vessels smaller than the pixel dimensions used for imaging can be visualized using a whole body 8-T MRI system.