Sesterterpenoids with Anticancer Activity.
Sesterterpenoids with Anticancer Activity.
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DOI：
10.2174/0929867322666150821101047
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发表时间：
2015
影响因子：
4.1
通讯作者：
Kiss R
中科院分区：
文献类型：
--
作者：
Evidente A;Kornienko A;Lefranc F;Cimmino A;Dasari R;Evidente M;Mathieu V;Kiss R
由于萜类天然产物具有复杂的、具有挑战性的合成结构和多样的生物活性，因此在科学文献中受到了极大的关注。根据生成萜烯的C5异戊二烯单元数，萜烯可分为半萜（C5）、单萜（C10）、双萜（C15）、二萜（C20）、酯萜（C25）、三萜（C30）和四萜（C40）。其中，甾体萜烯及其衍生物，即甾体萜，是真菌、海洋生物和植物中普遍存在的次生代谢产物。它们的结构多样性包括碳三环蛇烷、多环蒽酮、多环呋喃-2-酮、多环对苯二酚以及许多其他碳骨架。此外，它们中的许多具有很好的生物活性，包括细胞毒性和作为抗癌剂的相关潜力。本文综述了酯萜类化合物的天然来源，介绍了酯萜类化合物的名称、化学结构、生物学特性，重点介绍了酯萜类化合物的抗癌活性和相关文献。综述了各种酯萜类化合物作为抗癌药物的潜力。
Terpenes have received a great deal of attention in the scientific literature due to complex, synthetically challenging structures and diverse biological activities associated with this class of natural products. Based on the number of C5 isoprene units they are generated from, terpenes are classified as hemi- (C5), mono- (C10), sesqui- (C15), di- (C20), sester- (C25), tri (C30), and tetraterpenes (C40). Among these, sesterterpenes and their derivatives known as sesterterpenoids, are ubiquitous secondary metabolites in fungi, marine organisms, and plants. Their structural diversity encompasses carbotricyclic ophiobolanes, polycyclic anthracenones, polycyclic furan-2-ones, polycyclic hydroquinones, among many other carbon skeletons. Furthermore, many of them possess promising biological activities including cytotoxicity and the associated potential as anticancer agents. This review discusses the natural sources that produce sesterterpenoids, provides sesterterpenoid names and their chemical structures, biological properties with the focus on anticancer activities and literature references associated with these metabolites. A critical summary of the potential of various sesterterpenoids as anticancer agents concludes the review.