Injectable and thermosensitive supramolecular hydrogels by inclusion complexation between binary-drug loaded micelles and α-cyclodextrin
Injectable and thermosensitive supramolecular hydrogels by inclusion complexation between binary-drug loaded micelles and α-cyclodextrin
复制标题
DOI：
10.1016/j.msec.2017.03.151
复制
发表时间：
2017-07-01
影响因子：
7.9
通讯作者：
Lei, Jiandu
中科院分区：
文献类型：
--
作者：
Dai, Lin;Liu, Kefeng;Lei, Jiandu
载药胶束与水凝胶的结合可以克服单个组分作为药物载体的局限性。本文首次在水介质中制备了基于α -环糊精与8臂聚乙二醇-白桦酸(BA)/羟基喜树碱（HCPT）自组装的二元载药胶束包合的新型可注射超分子水凝胶。作为可逆的超分子组装行为，热敏水凝胶在特定温度下表现出独特的与结构相关的可逆凝胶-溶胶过渡性质。凝胶-溶胶转变温度由PEG链的长度和载药胶束与α -环糊精的质量比决定。此外，在体外和体内研究中，BA/ hcpt负载的水凝胶比游离药物和BA/ hcpt负载的胶束更有效。因此，这种具有独特结构和热敏性的可注射胶束水凝胶将成为许多智能递送应用的极具潜力的候选者。(C) 2017年Elsevier B.V.出版
The combination of drug loaded micelles and hydrogel could overcome the limitations with the use of the individual components as drug carriers. Herein, novel injectable supramolecular hydrogels based on the inclusion complexation between alpha-cyclodextrin and the binary-drug loaded micelles which self-assembled from 8arm-polyethylene glycol-betulinic acid (BA)/hydroxycamptothecin (HCPT) were first prepared in aqueous media. As the reversible supramolecular assembly behavior, the thermosensitive hydrogels showed distinctive structure-related reversible gel - sol transition properties at a particular temperature. The gel - sol transition temperature was determined by the length of the PEG chains and the mass ratio between the binary-drug loaded micelles and alpha-cyclodextrin. In addition, the BA/HCPT-loaded hydrogel showed more effectively than that of free drugs and BA/HCPT-loaded micelles for in vitro and in vivo studies. Hence, such an injectable micellar hydrogel with a distinctive structure and thermosensitive would be a highly potential candidate for many intelligent delivery applications. (C) 2017 Published by Elsevier B.V.