Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis.
Binder's syndrome due to prenatal vitamin K deficiency: a theory of pathogenesis.
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产前维生素 K 缺乏导致的宾德综合征：发病机制理论。
DOI：
10.1111/j.1834-7819.1992.tb05901.x
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发表时间：
1992
影响因子：
2.1
通讯作者：
L. Sheffield
中科院分区：
文献类型：
--
作者：
A. M. Howe;W. Webster;A. Lipson;Jane Halliday;L. Sheffield
有证据表明，人类怀孕期间维生素k缺乏可能是由于治疗性使用华法林或苯妥英引起的。本文报告了3例宾德氏综合征的妊娠史。一个与华法林暴露有关，一个与苯妥英暴露有关，一个与酗酒有关。有人提出宾德氏综合症可能是由于产前暴露于导致维生素k缺乏症的物质引起的。Sprague-Dawley大鼠从出生后第1 ~ 12周开始，每天给药华法林（100 mg/kg）和维生素K1 （10 mg/kg）。这种养生法会造成肝外维生素k缺乏。接受治疗的大鼠发育出明显的面部外观，其特征是鼻子明显缩小。组织学检查显示正常未钙化的中隔软骨广泛钙化。有人提出，鼻中隔软骨的正常生长对于鼻子和中脸轮廓的发育是必要的，并且只有在鼻中隔软骨未钙化的情况下才会正常生长。
There is evidence that vitamin K-deficiency during human pregnancy can be caused by the therapeutic use of warfarin or phenytoin. The pregnancy histories of three cases of Binder's syndrome are reported. One was associated with warfarin exposure, one with phenytoin exposure and one with alcohol abuse. It is proposed that Binder's syndrome can be caused by prenatal exposure to agents that cause vitamin K-deficiency. Sprague-Dawley rats were treated from postnatal day 1 to 12 weeks with daily doses of warfarin (100 mg/kg) and concurrent vitamin K1 (10 mg/kg). This regimen creates a net extra-hepatic vitamin K-deficiency. The treated rats developed with a distinct facial appearance characterized by a markedly reduced snout. Histological examination showed that the normally non-calcified septal cartilage was extensively calcified. It is proposed that normal growth of the septal cartilage is necessary for the development of the profile of the nose and midface and that normal growth will only take place while the septal cartilage is uncalcified.
影响因子：
7.5
作者：
PRICE, PA;KANEDA, Y
通讯作者：
KANEDA, Y