Combined Oral Contraceptives Increase High-Sensitivity C-Reactive Protein but Not Haptoglobin in Female Athletes
Combined Oral Contraceptives Increase High-Sensitivity C-Reactive Protein but Not Haptoglobin in Female Athletes
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DOI：
10.1007/s40279-016-0534-9
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发表时间：
2017-01-01
期刊：
影响因子：
9.8
通讯作者：
Curcio, Francesco
中科院分区：
文献类型：
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作者：
Cauci, Sabina;Francescato, Maria Pia;Curcio, Francesco
背景：目前还没有研究通过运动员的分层高敏感c反应蛋白（hsCRP）水平来评估口服激素避孕对慢性低度炎症的影响。探讨复方口服避孕药（OCs）对白人女运动员血清hsCRP、接触珠蛋白、甘油三酯和胆固醇的影响。方法意大利女运动员205例，平均年龄24 +/- 5.3岁，体重指数21 +/- 2.2 kg m(-2)；每周运动8.7 +/- 3.65 h(-1))。结果：与非OC使用者（n = 152）相比，评估了OC使用者（n = 53）的hsCRP进展水平。62.3%的OC使用者和13.2%的非OC使用者的hsCRP水平在3.0 - 1.0 mg L-1之间（OR = 10.9, 95% CI 5.26-22.5, P < 0.001）。保护性hsCRP水平(
Background No studies have examined the effects of oral hormonal contraception on chronic low-grade inflammation as assessed by stratified levels of high-sensitivity C-reactive protein (hsCRP) in athletes. We explored the impact of combined oral contraceptives (OCs) on serum hsCRP, haptoglobin, triglycerides and cholesterol in white female athletes.Methods Italian sportswomen (n = 205; mean age 24 +/- 5.3 years; body mass index 21 +/- 2.2 kg m(-2); sport activity 8.7 +/- 3.65 h week(-1)) were analyzed according to OC use.Results Progressive hsCRP levels were evaluated in OC users (n = 53) compared to non-OC users (n = 152). Levels of hsCRP from 3.0 to 1.0 mg L-1 were found in 62.3 % of OC users versus 13.2 % non-OC users (OR = 10.9, 95 % CI 5.26-22.5, P < 0.001). Protective hsCRP levels (