Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder
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DOI：
10.2147/ndt.s188340
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发表时间：
2018-01-01
影响因子：
3.2
通讯作者：
Liang, Ying
中科院分区：
文献类型：
--
作者：
Huang, Yichen;Shi, Xing;Liang, Ying
背景：肠道微生物群可以通过多种方式影响人类的行为和情绪。多项研究表明，抑郁症患者同时伴有肠道菌群失调，其中厚壁菌门与肠道屏障的保护功能有关。本研究旨在探讨厚壁菌门在重度抑郁症（MDD）患者中的变化及其作用。结果：MDD患者的α多样性指数低于健康对照组，差异有统计学意义（P < 0. 05）。厚壁菌门是MDD样品中减少最显著的门。共有13种生物标志物具有P值
Background: Gut microbiota can affect human behavior and mood in many ways. Several studies have shown that patients with depression were also accompanied with gut microbiota disorder, in which Firmicutes are related to the protective function of intestinal barrier. in this study, we explore the changes and effects of Firmicutes in the patients with major depressive disorder (MDD).Method: We recruited 54 subjects, including 27 patients with MDD. Fecal samples were collected for identification by 16S rRNA sequencing and bioinformatics analysis.Results: The study shows that the alpha diversity indices of MDD patients are lower than those of the healthy controls. Firmicutes is the most significantly decreased phylum in the MDD samples. There are totally 13 taxonomic biomarkers with P-value