Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy
Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy
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DOI：
10.1093/cercor/bhh200
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发表时间：
2005-07-01
期刊：
影响因子：
3.7
通讯作者：
Evans, AC
中科院分区：
文献类型：
--
作者：
Lerch, JP;Pruessner, JC;Evans, AC
阿尔茨海默病(AD)的特点是脑部病变的异质性分布。磁共振成像可用于研究活体AD皮质萎缩的区域分布。疾病特异性萎缩的一个标志是大脑皮质外套膜的厚度，这是通过自动3-D图像处理获得的。在这里，我们提供了36名受试者(17名对照和19名被诊断为可能患有AD的患者)的数据，他们被调查了整个大脑的皮质厚度。我们发现阿尔茨海默病患者的颞叶、眶前叶和顶叶皮质厚度显著降低，其中最显著的变化发生在内侧颞叶的局部皮质区域，轮廓为海马旁回，皮质厚度减少1.25毫米。此外，根据基线扫描和简易精神状态检查的时间衡量，局灶性皮质面积随着疾病的进展而减少。结果表明，这种方法能够检测AD患者整个大脑皮质厚度的变化，而不需要事先的解剖学定义。这里报道的变化的区域分布与AD神经病理变化分布的独立发现是一致的。此外，使用皮质厚度，我们提供了疾病中萎缩的直接量化指标。
Alzheimer's disease ( AD) is characterized by a heterogeneous distribution of pathological changes throughout the brain. Magnetic resonance imaging can be used to investigate the regional distribution of cortical atrophy in AD in vivo. One marker for the disease-specific atrophy is the thickness of the cortical mantle across the brain, obtained with automated 3-D image processing. Here, we present data from 36 subjects ( 17 controls and, 19 patients diagnosed as probable AD) investigated for cortical thickness across the entire brain. We show significant cortical thickness decline in AD in temporal, orbitofrontal and parietal regions, with the most pronounced changes occurring in the allocortical region of the medial temporal lobes, outlining the parahippocampal gyrus, and representing a loss of > 1.25 millimeters of cortical thickness. Moreover, focal cortical areas decline with progression of the disease as measured by time from baseline scan as well as the Mini-Mental State Exam. The results demonstrate the ability of this method to detect changes in cortical thickness in AD, across the entire brain, without need of prior anatomical definitions. The regional distribution of changes reported here is consistent with independent findings on the distribution of neuropathological alterations in AD. Using cortical thickness, moreover, we provide a direct quantitative index of atrophy in the disease.