Molecular and cellular basis of chemically induced immunotoxicity.
Molecular and cellular basis of chemically induced immunotoxicity.
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化学诱导免疫毒性的分子和细胞基础。
DOI：
10.1146/annurev.pa.27.040187.000323
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发表时间：
1987
影响因子：
12.5
通讯作者：
J. Dean
中科院分区：
文献类型：
--
作者：
M. Luster;J. A. Blank;J. Dean
免疫毒理学是研究职业性、无意或治疗性暴露于药物、环境化学品以及某些情况下的生物材料对免疫系统的不良影响。在本章中，我们将这些物质统称为“外源性物质”。“免疫毒性又细分为三个主要研究领域：（a）研究与人类和动物接触外源性物质有关的免疫学变化，包括宿主对传染病的抵抗力的变化;（B）研究接触外源性物质引起的变态反应和自身免疫;（c）在毒理学研究中采用分析免疫学方法。本章只着重于化学农药诱导的免疫调节，并介绍了几类免疫毒性外源性物质，强调细胞和分子的目标。主要在啮齿类动物中进行的实验室研究证明，免疫系统对化学损伤非常敏感（综述见1-6）。这种敏感性可能是由于异生素的一般性质（例如与大分子的反应性）以及免疫系统的复杂性质，包括抗原识别和加工;
Immunotoxicology is the study of adverse effects on the immune system resulting from occupational, inadvertent, or therapeutic exposure to drugs, environmental chemicals, and, in some instances, biological materials. For the purpose of this chapter, we refer to these substances collectively as "xenobiotics." Immunotoxicity is subdivided into three main research areas: (a) studies of altered immunological events associated with exposure of humans and animals to xenobiotics, including altered host resistance to infectious disease; (b) studies of allergy and autoimmunity resulting from xenobiotic exposure; and (c) implementation of analytical immunological methods into toxicology research. This chapter focuses only on chemical induced immunomodulation and describes several classes of irnmunotoxic xenobiotics, emphasizing cellular and molecular targets. Laboratory studies, conducted primarily in rodents, have provided evi dence that the immune system is very sensitive to chemical injury (reviewed in 1-6). This sensitivity is probably due as much to the general properties of a xenobiotic (e.g. reactivity with macromolecules) as to the complex nature of the immune system, which encompasses antigen recognition and processing;
甲基胆蒽和苯并蒽对三种近交系小鼠脾淋巴细胞中胚芽发生和芳烃羟化酶诱导的影响。
DOI：
10.1016/0192-0561(83)90003-6
发表时间：
1983
期刊：
International journal of immunopharmacology
影响因子：
--
作者：
Alfred,LJ;Wojdani,A
通讯作者：
Wojdani,A