Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion.
Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion.
复制标题
DOI：
--
复制
发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
M. Babbar;M. Sheikh
中科院分区：
文献类型：
--
作者：
M. Babbar;M. Sheikh
线粒体形态和代谢在细胞稳态中起着重要作用。最近的研究表明，线粒体形态的保真度在维持线粒体形状、数量、大小、膜电位、ATP合成、mtDNA、运动、信号传导、质量控制、细胞应激反应、线粒体自噬和凋亡等方面具有重要意义。这篇文章提供了当前状态的知识的裂变和融合机制的概述，重点是线粒体形态和细胞能量状态的调节机制。一些证据表明，线粒体分裂或融合的失调与线粒体功能障碍有关，线粒体功能障碍反过来影响线粒体自噬和细胞凋亡。代谢紊乱也与裂变或融合的失调有关，现有的证据表明线粒体裂变或融合反应与生物能量学之间存在双向相互作用。显然，需要更深入的研究来充分阐明控制线粒体裂变和融合的机制。预计这些研究的结果将提高对相关代谢紊乱的分子基础的理解，并促进更好的治疗方法的发展。
Mitochondrial morphology and metabolism play an important role in cellular homeostasis. Recent studies have shown that the fidelity of mitochondrial morphology is important in maintaining mitochondrial shape, number, size, membrane potential, ATP synthesis, mtDNA, motility, signaling, quality control, response to cellular stress, mitophagy and apoptosis. This article provides an overview of the current state of knowledge of the fission and fusion machinery with a focus on the mechanisms underlying the regulation of the mitochondrial morphology and cellular energy state. Several lines of evidence indicate that dysregulation of mitochondrial fission or fusion is associated with mitochondrial dysfunction, which in turn impacts mitophagy and apoptosis. Metabolic disorders are also associated with dysregulation of fission or fusion and the available lines of evidence point to a bidirectional interplay between the mitochondrial fission or fusion reactions and bioenergetics. Clearly, more in-depth studies are needed to fully elucidate the mechanisms that control mitochondrial fission and fusion. It is envisioned that the outcome of such studies will improve the understanding of the molecular basis of related metabolic disorders and also facilitate the development of better therapeutics.