The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice
The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice
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DOI：
10.1507/endocrj.k10e-221
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发表时间：
2011-03-20
影响因子：
2
通讯作者：
Yoshimatsu, Hironobu
中科院分区：
文献类型：
--
作者：
Arakawa, Mie;Masaki, Takayuki;Yoshimatsu, Hironobu
研究表明支链氨基酸（BCAA）与肥胖及相关代谢紊乱有关。我们研究了支链氨基酸（BCAA）对高脂（45%）饮食喂养的小鼠肥胖和葡萄糖/脂肪稳态的影响。将BCAA溶解在0.5%甲基纤维素中并加入到饮用水（BCAA.治疗组）。高脂饮食6周，支链氨基酸2周。与对照组相比，BCAA治疗组的体重增加几乎减少了7%，附睾脂肪组织（WAT）质量也减少了（p < 0.05）。补充支链氨基酸还降低了肝脏和骨骼肌甘油三酯（TG）浓度（p < 0.05）。BCAA处理组小鼠肝脏中的PPAR-alpha和解偶联蛋白（UCP）2水平以及骨骼肌中的PPAR-alpha和UCP 3水平均高于对照组（p < 0.05）。这些结果表明，在BCAA处理组中，肝脏和肌肉的TO浓度较低。BCAA影响肌肉和肝脏组织中PPAR-alpha和UCP的表达。
It has been demonstrated the involvement of branched-chain amino acids (BCAA) on obesity and related metabolic disorder. We investigated the effects of branched-chain amino acids (BCAA) on obesity and on glucose/fat homeostasis in mice fed on a high-fat (45%) diet. BCAA was dissolved in 0.5% methylcellulose and added to the drinking water (BCAA.-treated group). A high-fat diet was provided for 6 weeks and BCAA was given for 2 weeks. The BCAA-treated group gained almost 7% less body weight and had less epididymal adipose tissue (WAT) mass than the control group (p < 0.05). BCAA supplementation also reduced the hepatic and skeletal muscle triglyceride (TG) concentrations (p < 0.05). The hepatic levels of PPAR-alpha and uncoupling protein (UCP) 2, and the level of PPAR-alpha and UCP3 in the skeletal muscle were greater in die BCAA-treated group than in the control mice (p < 0.05). These results demonstrate that the liver and muscle TO concentration are less in BCAA-treated group. BCAA affects PPAR-alpha and UCP expression in muscle and liver tissue.