The neural basis of counting sequences
The neural basis of counting sequences
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DOI：
10.1016/j.neuroimage.2021.118146
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发表时间：
2021-05
期刊：
影响因子：
5.7
通讯作者：
Eli Zaleznik;Joonkoo Park
中科院分区：
文献类型：
--
作者：
Eli Zaleznik;Joonkoo Park
序列处理对于复杂行为至关重要，而计数序列在人类数字发展的基础上占有独特的地位。尽管如此，计数序列的神经基础仍然没有得到研究。我们假设，在成年人的计数序列将涉及代表的感觉，顺序，幅度，和语言代码，涉及区域的听觉，辅助运动，后顶叶，和额叶下部，分别。在功能磁共振成像扫描仪中，参与者听到了2 × 2 × 2设计的四个数字序列。这些序列是读或不读的（例如，5、6、7、8对5，6，7，9），排序或不排序（例如，5、6、7、8对8，5，7，6），并通过avoiceof一致或可变的身份发言。然后，通过测试连续性的影响（有序非相邻与有序相邻，例如，5、6、7、9 > 5、6、7、8）。违反连续性引起大脑活动的右额下回（IFG）和补充运动区（SMA）。相比之下，在听觉皮层中没有观察到这种激活，尽管违反声音识别在该区域招募强烈的活动。此外，在顶下小叶中没有观察到激活，尽管在该脑区观察到强烈的有序效应。这些研究结果表明，听计数序列不自动引起的感觉或幅度代码，但建议，在序列中的精确增量跟踪的机制，用于处理有序的协会在SMA和绑定到一个连贯的整体在IFG个别词汇项目的机制。
Sequence processing is critical for complex behavior, and counting sequences hold a unique place underlying human numerical development. Despite this, the neural bases of counting sequences remain unstudied. We hypothesized that counting sequences in adults would involve representations in sensory, order, magnitude, and linguistic codes that implicate regions in auditory, supplementary motor, posterior parietal, and inferior frontal areas, respectively. In an fMRI scanner, participants heard four-number sequences in a 2 × 2 × 2 design. The sequences wereadjacentor not (e.g., 5, 6, 7, 8 vs. 5, 6, 7, 9),orderedor not (e.g., 5, 6, 7, 8 vs. 8, 5, 7, 6), and were spoken by avoiceof consistent or variable identity. Then, neural substrates of counting sequences were identified by testing for the effect of consecutiveness (ordered nonadjacent versus ordered adjacent, e.g., 5, 6, 7, 9 > 5, 6, 7, 8) in the hypothesized brain regions. Violations to consecutiveness elicited brain activity in the right inferior frontal gyrus (IFG) and the supplementary motor area (SMA). In contrast, no such activation was observed in the auditory cortex, despite violations in voice identity recruiting strong activity in that region. Also, no activation was observed in the inferior parietal lobule, despite a robust effect of orderedness observed in that brain region. These findings indicate that listening to counting sequences do not automatically elicit sensory or magnitude codes but suggest that the precise increments in the sequence are tracked by the mechanism for processing ordered associations in the SMA and by the mechanism for binding individual lexical items into a cohesive whole in the IFG.