Coupled regulation of interleukin‐12 receptor beta‐1 of CD8+ central memory and CCR7‐negative memory T cells in an early alloimmunity in liver transplant recipients
Coupled regulation of interleukin‐12 receptor beta‐1 of CD8+ central memory and CCR7‐negative memory T cells in an early alloimmunity in liver transplant recipients
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肝移植受者早期同种免疫中 CD8+ 中枢记忆 T 细胞和 CCR7 阴性记忆 T 细胞的白细胞介素 12 受体 β1 的耦合调节
DOI：
10.1111/j.1365-2249.2010.04117.x
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发表时间：
2010
影响因子：
4.6
通讯作者：
Shinji Uemoto
中科院分区：
文献类型：
--
作者：
Hiroto Egawa;Keiya Ozawa;Y. Takada;Satoshi Teramukai;A. Mori;K. Ogawa;T. Kaido;Yasuhiro Fujimoto;Y. Kawaguchi;Etsuro Hatano;Hiroshi Sato;M. Ono;Kenji Takai;K. Tanaka;Shinji Uemoto
本研究探讨了活体肝移植（LDLT）后CD 8 + T细胞亚群对同种免疫和感染免疫的反应。早期同种免疫：根据移植后病程将56例受者分为三种类型; I型表现出移植后病程平稳，II型发展为严重脓毒症，导致多器官功能障碍综合征或再次移植，III型伴有急性排斥反应。在23例I型受体中，中枢记忆T细胞的白细胞介素（IL）-12受体β-1（Rβ1）+细胞（IL-12 R β1+ TCM）高于移植前水平。在16例II型受体中，术后第5天（POD）IL-12 R β1+ TCM显著低于移植前水平。在17名III型受体中，IL-12 R β1+ TCM在更长时间内下降，直至术后第10天。沿着IL-12 R β1+ TCM的下调，CCR 7阴性亚群（CNS）的IL-12 R β1+细胞以及穿孔素、干扰素（IFN）-γ和肿瘤坏死因子（TNF）-α逐渐减少，导致效应物和细胞毒性的下调。IL-12 R β1+ TCM的下调被认为是由于同种抗原致敏的T细胞募集到移植物中，然后它们进入次级淋巴器官，导致移植物破坏。感染免疫力：响应于移植后感染，产生了具有增强效应子和细胞毒性能力的免疫活性记忆T细胞，伴随沿着IL-12 R β1+ TCM的上调和CNS中的增加，显示IL-12 R β1+细胞的最高水平。总之，这项工作证明了TCM和CNS的IL-12 R β1+细胞以紧密耦合的方式受到调节，并且IL-12 R β1+ TCM的表达水平在控制同种免疫和感染免疫中起着至关重要的作用。
This study investigated how CD8+ T cell subsets respond to allo‐ and infectious immunity after living donor liver transplantation (LDLT). Early alloimmunity: 56 recipients were classified into three types according to the post‐transplant course; type I demonstrated uneventful post‐transplant course, type II developed severe sepsis leading to multiple organ dysfunction syndrome or retransplantation and type III with acute rejection. In 23 type I recipients, the interleukin (IL)‐12 receptor beta‐1 (Rβ1)+ cells of central memory T cells (Il‐12Rβ1+ TCM) were increased above the pretransplant level. In 16 type II recipients, IL‐12Rβ1+ TCM was decreased markedly below the pretransplant level on postoperative day (POD) 5. In 17 type III recipients, IL‐12Rβ1+ TCM was decreased for a more prolonged period until POD 10. Along with down‐regulation of IL‐12Rβ1+ TCM, the IL‐12Rβ1+ cells of CCR7‐negative subsets (CNS) as well as perforin, interferon (IFN)‐γ and tumour necrosis factor (TNF)‐α decreased gradually, resulting in the down‐regulation of effectors and cytotoxicity. The down‐regulation of IL‐12Rβ1+ TCM was suggested to be due to the recruitment of alloantigen‐primed T cells into the graft, and then their entry into the secondary lymphoid organ, resulting in graft destruction. Infectious immunity: immunocompetent memory T cells with the capacity to enhance effectors and cytotoxicity were generated in response to post‐transplant infection along with both up‐regulation of the IL‐12Rβ1+ TCM and an increase in the CNS showing the highest level of IL‐12Rβ1+ cells. In conclusion, this work demonstrated that the IL‐12Rβ1+ cells of TCM and CNS are regulated in a tightly coupled manner and that expression levels of IL‐12Rβ1+ TCM play a crucial role in controlling allo‐ and infectious immunity.
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Interleukin-12：同种异体移植受者中可能的细胞毒性 T 淋巴细胞分化因子。
DOI：
--
发表时间：
1995
期刊：
Transplantation proceedings.
影响因子：
--
作者：
Gish,RG;Krams,SM;Martinez,OM
通讯作者：
Martinez,OM
影响因子：
15.9
作者：
Waldrop, SL;Pitcher, CJ;Picker, LJ
通讯作者：
Picker, LJ
影响因子：
15.9
作者：
Adams, AB;Williams, MA;Larsen, CP
通讯作者：
Larsen, CP
白细胞介素 12 (IL-12) 驱动的体外和体内同种免疫反应：对 IL-12 受体 β1 亚基的需求。
影响因子：
6.2
作者：
Piccotti,JR;Li,K;Chan,SY;Eichwald,EJ;Bishop,DK
通讯作者：
Bishop,DK