ACCUMULATION OF LABELLED VITAMIN B12 IN SOME TRANSPLANTED TUMOURS
ACCUMULATION OF LABELLED VITAMIN B12 IN SOME TRANSPLANTED TUMOURS
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DOI：
10.1002/ijc.2910030518
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发表时间：
1968-01-01
影响因子：
6.4
通讯作者：
ULLBERG, S
中科院分区：
文献类型：
--
作者：
FLODH, H;ULLBERG, S
使用全身放射自显影和脉冲计数研究了标记维生素B12在四种不同类型移植肿瘤中的蓄积。肿瘤为90 Sr诱导的软纤维母细胞性骨肉瘤、自发性乳腺癌、埃利希腹水和莫洛尼病毒诱导的肿瘤。90Sr诱导的软肉瘤是生长最快的肿瘤，显示出最大的放射性B12摄取，浓度高于任何正常组织。在所有肿瘤中，放射性定位于外周，仍然活跃生长的部分。提示B12的积累与细胞生长速度有关，B12是细胞快速增殖所必需的。
The accumulation of labelled vitamin B12in four different kinds of transplanted tumour was studied using whole‐body autoradiography and impulse counting. The tumours were90Sr‐induced soft fibroblastic osteosarcomas, spontaneous mammary carcinomas, Ehrlich ascites and Moloney virus‐induced tumours. The90Sr‐induced soft sarcoma, which was the most rapidly growing tumour, showed the greatest uptake of radio‐B12, the concentration being higher than in any normal tissue. In all tumours the radioactivity was localized to the peripheral, still actively growing parts. It is suggested that a connection exists between growth rate and accumulation of B12and that B12is needed for rapid cell multiplication.