Odorant receptor-derived cAMP signals direct axonal targeting
Odorant receptor-derived cAMP signals direct axonal targeting
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DOI：
10.1126/science.1131794
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发表时间：
2006-10-27
期刊：
影响因子：
56.9
通讯作者：
Sakano, Hitoshi
中科院分区：
文献类型：
--
作者：
Imai, Takeshi;Suzuki, Misao;Sakano, Hitoshi
在哺乳动物中，气味受体（OR）将嗅觉感觉神经元（OSN）的轴突导向嗅球中的目标。我们表明，调节轴突引导分子表达的环磷酸腺苷（cAMP）信号对于OR指导的轴突投射至关重要。对OR、刺激性G蛋白、cAMP依赖性蛋白激酶和cAMP反应元件结合蛋白的遗传操作使轴突投射位点沿着嗅球的前后轴移动。因此，是OR衍生的cAMP信号，而不是OR分子的直接作用，决定了OSN的靶向目的地。
In mammals, odorant receptors (ORs) direct the axons of olfactory sensory neurons (OSNs) toward targets in the olfactory bulb. We show that cyclic adenosine monophosphate ( cAMP) signals that regulate the expression of axon guidance molecules are essential for the OR-instructed axonal projection. Genetic manipulations of ORs, stimulatory G protein, cAMP-dependent protein kinase, and cAMP response element - binding protein shifted the axonal projection sites along the anterior-posterior axis in the olfactory bulb. Thus, it is the OR-derived cAMP signals, rather than direct action of OR molecules, that determine the target destinations of OSNs.