OPINION Autoantibodies as predictive tools in systemic sclerosis
OPINION Autoantibodies as predictive tools in systemic sclerosis
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DOI：
10.1038/nrrheum.2009.238
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发表时间：
2010-02-01
影响因子：
33.7
通讯作者：
Denton, Christopher P.
中科院分区：
文献类型：
--
作者：
Nihtyanova, Svetlana I.;Denton, Christopher P.
自身抗体在系统性硬化症（SSc）中的发病作用尚不清楚，但这些自身抗体已被确定为疾病结局和患有这种疾病的患者的器官并发症模式的强有力预测因子。三种最常见的SSc特异性自身抗体类型-抗着丝粒抗体、抗拓扑异构酶抗体和抗RNA聚合酶III抗体-在超过50%的患者中发现;每种抗体的存在通常不包括其他抗体。尽管很少观察到，但针对U3 RNP和Th/To的抗体也对硬皮病具有特异性，而抗Pm/Scl、抗Ku和抗U1 RNP抗体主要见于重叠综合征患者。高达11%的SSc患者的抗核抗体检测结果为阴性。自身抗体特异性与疾病表现和结局之间存在密切联系，这使得自身抗体成为SSc患者的重要评估工具。
The pathogenetic role of autoantibodies in systemic sclerosis (SSc) remains unclear, but these autoantibodies have been established as strong predictors of disease outcome and the pattern of organ complications in patients with this condition. The three most frequently observed types of SSc-specific autoantibody-anti-centromere antibodies, anti-topoisomerase antibodies and antiRNA polymerase III antibodies-are found in over 50% of patients; the presence of each is generally exclusive of the others. Although a lot less frequently observed, antibodies directed against U3RNP and Th/To are also specific for scleroderma, whereas anti-Pm/Scl, anti-Ku and anti-U1RNP antibodies are seen mainly in patients with overlap syndromes. Up to 11% of patients with SSc can test negative for antinuclear antibodies. Strong links exist between autoantibody specificities and disease presentation and outcome, which make autoantibodies essential assessment tools in patients with SSc.