Obstructive sleep apnea syndrom during pregnancy: prevalence of main symptoms and relationship with pregnancy induced-hypertension and intra-uterine growth retardation
Obstructive sleep apnea syndrom during pregnancy: prevalence of main symptoms and relationship with pregnancy induced-hypertension and intra-uterine growth retardation
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DOI：
10.1016/j.revmed.2006.01.015
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发表时间：
2006-04-01
影响因子：
0.9
通讯作者：
Pierre, F.
中科院分区：
文献类型：
--
作者：
Calaora-Tournadre, D.;Ragot, S.;Pierre, F.
Objective. - 目的探讨阻塞性睡眠呼吸暂停综合征（OSAS）主要症状的发生率及其与妊娠高血压综合征（PIH）和宫内生长迟缓（IGR）的关系。- 在排除多胎妊娠后，对产后期间完成的438份询问表进行了分析。收集的数据包括人口学特征、产科事件、妊娠末期睡眠障碍、打鼾筛查和埃普沃思评分的警觉性问题。- 据报道，45%的患者在怀孕期间有习惯性打鼾。其中，85%的孕妇在怀孕前不打鼾。白天嗜睡者占84.5%，埃普沃思评分显著增高（P <0.0001）。妊高征的患病率为4.5%，有两个明显独立的危险因素：体重指数（OR = 1，1）和打鼾与警觉性增加之间的关联（OR = 2，6）。IGR无统计学差异。- SAS症状在怀孕期间很常见，打鼾似乎与PIH有关。然而，多导睡眠图数据还不足以解释病理生理机制，并在怀孕期间找到相关的诊断标志物。(c)2006年爱思唯尔SAS。
Objective. - To investigate the frequency of main symptoms of Obstructive Sleep Apnea Syndrom (OSAS) and their relationship with Pregnancy Induced-Hypertension (PIH) as well as Intrauterine Growth Retardation (IGR) as suggested by recent studies.Methodology. - Four hundred (and) thirty-eight enquiry forms completed during post-partum period were analysed, after exclusion of multiple pregnancies. Collected data were demographic characteristics, obstetrical events, sleep disorders during last trimester, screening of snoring and vigilance troubles with an Epworth score.Results. - Forty-five percentages of the patients reported to have habitual snoring during pregnancy. Among these, 85% were non-snorers before pregnancy. Daytime somnolence concerned 84,5% of the population with an Epworth score significatively increased (P < 0,000 1). The prevalence of PIH was found to be 4,5%, with two apparently independent risk factors: the body mass index (OR = 1, 1) and an association between snoring and increased vigilance trouble (OR = 2,6). No statistical difference was found concerning IGR.Conclusions. - SAS symptoms are frequent during pregnancy and snoring appears to be linked with PIH. However, polysomnographic data are not yet sufficient to explain pathophysiological mechanisms and find relevant diagnostic markers during pregnancy. (c) 2006 Elsevier SAS.