Exercise, exerkines, and cardiometabolic health: from individual players to a team sport.
Exercise, exerkines, and cardiometabolic health: from individual players to a team sport.
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DOI：
10.1172/jci172916
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发表时间：
2023-07-03
影响因子：
15.9
通讯作者：
Gerszten, Robert E.
中科院分区：
文献类型：
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作者：
Robbins, Jeremy M.;Gerszten, Robert E.
运动带来了许多有益的影响，这些影响超出了单个器官系统，提供了全身健康益处。在这里，我们讨论运动在心血管健康中的作用。我们总结了心脏代谢疾病中人类运动研究的主要发现。接下来，我们描述了我们目前对急性运动和运动训练反应中发生的心脏特异性底物代谢的理解。随后，我们专注于运动刺激的循环生化物质（“运动因子”）作为理解运动的全球健康回路的一个范例，并在强调心血管健康和疾病相关的运动因子之前讨论这一新兴领域的重要概念。最后，本次审查确定了运动科学领域仍然存在的差距，以及将生物学见解转化为人类健康改善的机会。
Exercise confers numerous salutary effects that extend beyond individual organ systems to provide systemic health benefits. Here, we discuss the role of exercise in cardiovascular health. We summarize major findings from human exercise studies in cardiometabolic disease. We next describe our current understanding of cardiac-specific substrate metabolism that occurs with acute exercise and in response to exercise training. We subsequently focus on exercise-stimulated circulating biochemicals (“exerkines”) as a paradigm for understanding the global health circuitry of exercise, and discuss important concepts in this emerging field before highlighting exerkines relevant in cardiovascular health and disease. Finally, this Review identifies gaps that remain in the field of exercise science and opportunities that exist to translate biologic insights into human health improvement.