A concise route to virginiamycin M2
A concise route to virginiamycin M2
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DOI：
10.1016/j.tet.2019.04.060
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发表时间：
2019-06-14
期刊：
影响因子：
2.1
通讯作者：
Seiple, Ian B.
中科院分区：
文献类型：
--
作者：
Li, Qi;Seiple, Ian B.
结构复杂的天然产品的模块化全合成路线为获得化学多样性提供了有用的途径。在这里，我们报告了一个简洁的路线维吉尼亚霉素M2，一个成员的A组链阳性菌素类天然产物，抑制细菌蛋白质的合成。我们的方法具有最长的线性序列的6个步骤，从7个简单的积木，是最短的和最高产量的合成的任何成员的链阳性菌素类报道。我们相信，这条途径将使获得未开发的结构多样性，并可能作为一个有用的工具，以提高抗生素的链阳菌素类的治疗潜力。(C)2019爱思唯尔有限公司版权所有。
Modular, fully synthetic routes to structurally complex natural products provide useful avenues to access chemical diversity. Herein we report a concise route to virginiamycin M2, a member of the group A streptogramin class of natural products that inhibits bacterial protein synthesis. Our approach features a longest linear sequence of six steps from 7 simple building blocks, and is the shortest and highest yielding synthesis of any member of the streptogramin class reported to date. We believe this route will enable access to unexplored structural diversity and may serve as a useful tool to improve the therapeutic potential of the streptogramin class of antibiotics. (C) 2019 Elsevier Ltd. All rights reserved.