Functional diversity of the superfamily of K+ transporters to meet various requirements
Functional diversity of the superfamily of K+ transporters to meet various requirements
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DOI：
10.1515/hsz-2015-0123
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发表时间：
2015-09-01
影响因子：
3.7
通讯作者：
Haenel, Inga
中科院分区：
文献类型：
--
作者：
Diskowski, Marina;Mikusevic, Vedrana;Haenel, Inga
K+转运体的超家族结合了植物、真菌、细菌和古生菌的蛋白质，这些蛋白质可以跨膜转运K+和/或Na+。这些蛋白质是渗透调节、pH动态平衡和抵抗高盐度和干旱的关键成分。超家族的成员与K+通道如KCSA密切相关，但也显示出几个显着的差异，这归因于它们功能的改变。本文重点介绍了细菌超家族成员KtrB、TrkH和KdpA在功能上的差异。根据最近解决的Ktr和Trk系统的结构，讨论了该家族内的功能变异以及与MPM型K+通道的比较。
The superfamily of K+ transporters unites proteins from plants, fungi, bacteria, and archaea that translocate K+ and/or Na+ across membranes. These proteins are key components in osmotic regulation, pH homeostasis, and resistance to high salinity and dryness. The members of the superfamily are closely related to K+ channels such as KcsA but also show several striking differences that are attributed to their altered functions. This review highlights these functional differences, focusing on the bacterial superfamily members KtrB, TrkH, and KdpA. The functional variations within the family and comparison to MPM-type K+ channels are discussed in light of the recently solved structures of the Ktr and Trk systems.