HEPATOCELLULAR-CARCINOMA DETECTED BY IODIZED OIL - USE OF ANTICANCER AGENTS
HEPATOCELLULAR-CARCINOMA DETECTED BY IODIZED OIL - USE OF ANTICANCER AGENTS
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DOI：
10.1148/radiology.154.1.2981114
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发表时间：
1985-01-01
期刊：
影响因子：
19.7
通讯作者：
HOSOGI, Y
中科院分区：
文献类型：
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作者：
OHISHI, H;UCHIDA, H;HOSOGI, Y
对97例肝癌患者行经导管动脉栓塞术。通过肝动脉注入含有抗癌药物的碘油（碘油），然后注入明胶泡沫颗粒。乳剂选择性地保留在肿瘤血管中，也保留在小的子结节中，这些小结节在TAE前无法通过血管造影或计算机断层扫描（CT）检测到。硫代酚在肿瘤中残留1年以上。TAE术后，主要肿瘤及小子结节在CT上表现为明显高密度区。在大多数患者中，TAE后肿瘤大小减小，血清α - α降低。所有初始水平超过400ng /ml的患者的胎蛋白水平均降低。由于硫噻酚在肿瘤血管中的长期蓄积，该方法被认为不仅对肝肿瘤的治疗有效，而且对tae后肿瘤变化的评估和小结节的诊断也很有用。
Transcatheter arterial embolization (TAE) was performed in 97 patients with hepatocellular carcinoma. Ethiodol (iodized oil) containing an anticancer drug was infused via the hepatic artery followed by Gelfoam particles. The Ethiodol emulsion was selectively retained in the tumor vessels and also remained in the small daughter nodules that could not be detected by angiography or computed tomography (CT) prior to TAE. Ethiodol remained in the tumor for more than 1 yr. Following TAE, main tumors and small daughter nodules appeared as areas of markedly high density on CT. In most patients there was a reduction in the tumor size following TAE, and serum .alpha. fetoprotein levels were reduced in all patients whose initial levels had exceeded 400 ng/ml. This method is considered to be effective not only for treatment of hepatic tumor but also useful for evaluation of post-TAE changes in the tumor and diagnosis of small daughter nodules, due to the long-term accumulation of Ethiodol in tumor vessels.