Association Between Recent Cannabis Consumption and Withdrawal-Related Symptoms During Early Abstinence Among Females With Smoked Cocaine Use Disorder.
Association Between Recent Cannabis Consumption and Withdrawal-Related Symptoms During Early Abstinence Among Females With Smoked Cocaine Use Disorder.
复制标题
患有吸食可卡因使用障碍的女性早期戒断期间近期大麻消费与戒断相关症状之间的关联。
DOI：
10.1097/adm.0000000000000599
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发表时间：
2020
影响因子：
5.5
通讯作者：
Grassi-Oliveira,Rodrigo
中科院分区：
文献类型：
--
作者：
Viola,ThiagoWendt;Sanvicente-Vieira,Breno;Kluwe-Schiavon,Bruno;Rothmann,LeonardoMelo;Mélo-Pereira,JoãoVítorNóbregaE;Bicca,Carla;OttoliaNiederauer,JoãoPaulo;Schmitz,Joy;Grassi-Oliveira,Rodrigo
背景：大麻对其他药物使用障碍治疗服务的临床结果的影响尚不清楚。本研究的主要目的是调查最近大麻消费对可卡因戒断和抑郁症状严重程度的影响，在为期3周的可卡因使用障碍女性住院治疗计划中。本研究的第二个目标是测试最近的酒精或烟草使用对上述outcomes.Methods的影响：这是一个纵向研究，2个评估时间点：在注册和出院后，从医疗管理的重症住院部。样本由214名早期戒断的女性可卡因使用障碍。使用考辛斯选择性严重程度评估（CSSA）和贝克抑郁量表（BDI-II）测量考辛斯戒断和抑郁症状。使用成瘾严重程度指数（ASI-6）评估近期物质使用情况。结果：可卡因使用障碍和近期频繁使用大麻的患者在住院治疗3周后报告了更严重的可卡因戒断和抑郁症状。无论是最近的酒精或烟草的使用与增加的综援或BDI的结果，这表明这些物质发挥了较小的作用，最近的大麻使用在影响戒断相关的symptoms.Conclusions：最近的大麻使用的评估可能有助于确定患者需要额外的治疗，以管理严重的可卡因戒断症状和抑郁症状在早期禁欲。
Background:The effects of cannabis on clinical outcomes of treatment services for other drug use disorders remains unclear. The primary aim of the current study was to investigate the effects of recent cannabis consumption on the severity of cocaine withdrawal and depressive symptoms during a 3-week inpatient treatment program for women with cocaine use disorder. The second goal of this study was to test the effect of recent alcohol or tobacco use on the aforementioned outcomes.Methods:This was a longitudinal study with 2 assessment time points: at enrollment and upon discharge from a medically managed intensive inpatient unit. The sample was composed of 214 early abstinence females with cocaine use disorder. Cocaine withdrawal and depressive symptoms were measured using the Cocaine Selective Severity Assessment (CSSA) and the Beck Depressive Inventory (BDI-II). Recent substance use was evaluated using the Addiction Severity Index (ASI-6).Results:Patients with cocaine use disorder and with frequent recent cannabis use reported higher severity of cocaine withdrawal and depressive symptoms after 3 weeks of inpatient treatment. Neither recent alcohol nor tobacco use was associated with increased CSSA or BDI outcomes, suggesting these substances play a minor role compared to recent cannabis use in affecting withdrawal-related symptoms.Conclusions:The assessment of recent cannabis use may help identify patients in need of additional treatment to manage severe cocaine withdrawal symptoms and depressive symptoms during early abstinence.