Forming Consensus To Advance Urobiome Research.
Forming Consensus To Advance Urobiome Research.
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DOI：
10.1128/msystems.01371-20
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发表时间：
2021-08-31
期刊：
影响因子：
6.4
通讯作者：
Wolfe AJ
中科院分区：
文献类型：
--
作者：
Brubaker L;Gourdine JF;Siddiqui NY;Holland A;Halverson T;Limeria R;Pride D;Ackerman L;Forster CS;Jacobs KM;Thomas-White KJ;Putonti C;Dong Q;Weinstein M;Lukacz ES;Karstens L;Wolfe AJ
尿生物群系研究有可能促进对各种疾病的理解，包括下尿路症状和肾脏疾病。许多科学领域都受益于早期的研究方法共识，以促进更大的共同利益。该共识文件由目前从事尿生物组研究的专家研究人员（UROBIOME 2020会议参与者）开发，旨在通过采用共同的核心研究实践来促进该领域的标准化和进步。我们提出了一个标准化的命名以及标本采集，保存，储存和处理的考虑。尿生物群系研究设计的最佳实践包括我们提出的标准元数据元素作为核心元数据收集的一部分。虽然这是不切实际的，按照固定的分析程序时，分析urobiome数据，我们提出的指导方针，记录和报告数据来源于urobiome研究。我们提供了这第一个共识文件，并期望随着我们领域的进展，随后进行修订。
Urobiome research has the potential to advance the understanding of a wide range of diseases, including lower urinary tract symptoms and kidney disease. Many scientific areas have benefited from early research method consensus to facilitate the greater, common good. This consensus document, developed by a group of expert investigators currently engaged in urobiome research (UROBIOME 2020 conference participants), aims to promote standardization and advances in this field by the adoption of common core research practices. We propose a standardized nomenclature as well as considerations for specimen collection, preservation, storage, and processing. Best practices for urobiome study design include our proposal for standard metadata elements as part of core metadata collection. Although it is impractical to follow fixed analytical procedures when analyzing urobiome data, we propose guidelines to document and report data originating from urobiome studies. We offer this first consensus document with every expectation of subsequent revision as our field progresses.