Characterization of Parotid Tumors With Dynamic Susceptibility Contrast Perfusion-Weighted Magnetic Resonance Imaging and Diffusion-Weighted MR Imaging
Characterization of Parotid Tumors With Dynamic Susceptibility Contrast Perfusion-Weighted Magnetic Resonance Imaging and Diffusion-Weighted MR Imaging
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DOI：
10.1097/rct.0000000000000486
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发表时间：
2017-01-01
影响因子：
1.3
通讯作者：
Ashmalla, Germeen Albair
中科院分区：
文献类型：
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作者：
Razek, Ahmed Abdel Khalek Abdel;Samir, Sieza;Ashmalla, Germeen Albair
目的：材料与方法：对48例腮腺肿瘤患者进行磁敏感对比剂动态灌注成像（MRI）和扩散加权成像（DWI）研究（27名男性，21名女性;年龄15-75岁;意思是，45岁）接受动态磁敏感造影剂灌注的腮腺肿瘤患者-在团注钆喷酸葡胺后进行MR加权成像和扩散加权成像。结果：腮腺恶性肿瘤的动态磁敏感对比百分比（DSC%）为33.53% ± 3.99%，腮腺良性肿瘤的DSC%为22.29% ± 4.13%，两者差异有显著性（P = 0.001）。用于区分腮腺肿瘤良恶性的DSC%和ADC阈值分别为26.5%和1.07 x 10 - 3 mm 2/s，曲线下面积（AUC）分别为0.96和0.81。腮腺恶性肿瘤的DSC%与Warthin瘤相比有显著性差异（P = 0.001）。用于区分恶性肿瘤与Warthin肿瘤的临界DSC%为26.9%，AUC为0.99。多形性腺瘤与Warthin瘤的DSC%和ADC值差异有显著性（P = 0.001）。用于区分多形性腺瘤和Warthin瘤的DSC%和ADC的阈值分别为22.5%和0.99 x 10（-3）mm（2）/s，AUC分别为0.88和0.98。动态磁敏感对比增强灌注加权磁共振成像和扩散-磁共振加权成像是一种无创性的有前途的方法，用于鉴别腮腺肿瘤的良恶性，并对某些良性腮腺肿瘤进行定性。
Purpose: To characterize parotid tumorswith dynamic susceptibility contrast perfusion-weighted magnetic resonance (MR) imaging and diffusionweighted MR imaging.Material and Methods: Prospective study was conducted upon 48 consecutive patients (27 men, 21 women; aged 15-75 years; mean, 45 years) with parotid tumors that underwent dynamic susceptibility contrast perfusion-weighted MR imaging was performed after bolus injection of gadopentate dimeglumine and diffusion-weighted MR imaging. The dynamic susceptibility contrast percentage (DSC%) and apparent diffusion coefficient (ADC) values of parotid tumors were calculated and correlated with histopathological findings.Results: The DSC% of malignant parotid tumors (33.53% +/- 3.99%) was significantly different (P = 0.001) from that of benign parotid tumors (22.29% +/- 4.13%). The threshold values of DSC% and ADC used in differentiating malignant from benign parotid tumors were 26.5% and 1.07 x 10(-3) mm(2)/s, respectively, with area under the curve (AUC) of 0.96 and 0.81, respectively. The DSC% of malignant parotid tumors was significantly different from that ofWarthin tumors (P = 0.001). The cutoff DSC% used to differentiate malignancy from Warthin tumors was 26.9% with an AUC of 0.99. There was a significant difference in DSC% and ADC values between pleomorphic adenomas and Warthin tumors (P = 0.001). The threshold values of DSC% and ADC used in differentiating pleomorphic adenomas from Warthin tumors was 22.5% and 0.99 x 10(-3) mm(2)/s, respectively, with AUC of 0.88 and 0.98, respectively.Conclusions: Dynamic susceptibility contrast-enhanced perfusion-weighted MRimaging and diffusion-weighted MRimaging are noninvasive promising methods that are used for differentiation of malignant from benign parotid tumors and for characterization of some benign parotid tumors.